Do Fatty Acids Cross the Blood Brain Barrier, if yes then why no Beta Oxidation in the brain? - USMLE Forums
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Old 05-11-2011
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Neuro Do Fatty Acids Cross the Blood Brain Barrier, if yes then why no Beta Oxidation in the brain?

Do fatty acids pass the blood brain barrier? If yes how they are used in the CNS? Do we have beta oxidation in the brain?
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Old 05-11-2011
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Quote:
Originally Posted by life9 View Post
do fatty acids pass BBB? if yes how they are used in CNS ?

Brain only feeds on glucose and rarely rarely on ketone bodies. That's why hypoglycemia is bad for your brain, it can not function without glucose.
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Old 05-11-2011
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i did not get the answer to my q.
why brain does not use fatty acids? should not lipid solubals be able to pass BBB?
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Old 05-11-2011
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Yes fatty acids definitely cross the blood brain barrier and enter into brain cells. However, the brain barely use this for energy and it's not known why.

Some people suggested the lack of certain beta oxidation enzymes as the cause as you can see in this article;
http://www.jbc.org/content/262/27/13027.abstract
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Old 05-12-2011
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as far as i know and acc to kaplan, FA do not cross the BBB and that is the reason they are not utilised by the brain..its only in prolonged states of fasting that the brain gains the capability to use ketone bodies and even in that state it only provides two third of the energy requirement
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Old 05-12-2011
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Quote:
Originally Posted by life9 View Post
Do fatty acids pass the blood brain barrier? If yes how they are used in the CNS? Do we have beta oxidation in the brain?
Initial studies stated that fatty acids could not enter the brain.
Recent studies propose that the blood brain barrier has mechanisms for selective uptake of certain types of fatty acids, e.g. essential fatty acids. These mechanisms have not been yet clearly elucidated. For example, fatty acid transporters proteins, monocarboxylic acid transporters and certain lipoproteins receptors have been described in the endothelial cells of the BBB. Other investigators propose that FA can readably cross the BBB by using a reversible flip-flop mechanism of simple diffusion. The function and the pathways the brain uses for utilization of fatty acids are also not well understood.

Also, future research areas have been identified and clarified by the second International Workshop on "Brain Uptake and Utilization of Fatty Acids, Lipids and Lipoproteins: Application to Neurological Disorders". We should expect future discoveries on these matters.

References:
http://www.ncbi.nlm.nih.gov/pubmed/17901540
http://www.ncbi.nlm.nih.gov/pubmed/11478373
http://www.ncbi.nlm.nih.gov/pubmed/17901559

Last edited by jorgemorales; 05-12-2011 at 02:41 AM.
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