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Old 05-12-2011
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Question PKU and Pregnacy Risk!

Which trimester in the pregnancy the most risky for the fetus to get PKU if the mother ingested a lot of Phenylalanine ??

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Old 06-07-2011
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Mothers with higher phenylalanine levels are more likely to have babies with birth defects than mothers with lower phenylalanine levels, especially during first trimester.

women with poorly controlled PKU during a pregnancy put their baby at risk for delayed development, mental retardation, microcephaly, poor overall growth, heart defects, and other structural birth defects. These complications are due to the ability of high levels of phenylalanine and its metabolites to directly cause birth defects and not because the baby has PKU.

The most critical time period of fetal development is during the first three months of pregnancy when the organs systems form. It is believed that during this time period high phenylalanine and its metabolites in the mothers' blood plasma can cross the placenta and directly effect the developing embryo by inducing birth defects. However, in the latter months the fetal brain continues to mature and abnormally high levels of phenylalanine can also influence brain development at that time. Therefore, it is important to maintain normal blood phenylalanine levels throughout pregnancy.
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