The histology of ostoeblastic metastatic prostate tumor? - USMLE Forums
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  #1  
Old 05-15-2011
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Microscope The histology of ostoeblastic metastatic prostate tumor?

What will the histological picture of metastatic osteoblastic increase in bone be? (in prostate cancer)
1. aggregates of plasma cells and plasmablasts
2. nests of epithelial cells joined by bridges and containing keratin pearls
3. plemorphic epithelial cells forming duct-like structures
4. sheets of small blue cells
5. sheets of uniform cells divided into lobules with thin fibrous septa and intervening lymphocytes
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  #2  
Old 05-15-2011
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this is a good one

Last edited by add1; 05-15-2011 at 07:44 AM.
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Old 05-15-2011
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Not really sure! But I think its a woven pattern of bone seen in the osteoblastic metastases so I would go with - 5. sheets of uniform cells divided into lobules with thin fibrous septa and intervening lymphocytes

Other useful diagnostic features of Osteoblastic Metastasis -
- Increased alkaline phosphatase
- Radiodense (as compared to osteolytic which is radiolucence)
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Old 05-20-2011
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since most of the prostate cancers are adenocarcinoma , i would go wid
3.. plemorphic epithelial cells forming duct-like structures..

wat is the actual answer...?kindly explain wid reasons...
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Old 05-20-2011
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Default 3

pancreatic Adenocarcinoma mets should have gland like arrangement of the metastatic tissue
Answer should be option 3
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Old 05-20-2011
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I think its 3. because prostate cancer's have ducts, so mets to the bone should look the same. Please tell us the answer

Also, the title of you posts says "pancreatic cancer" when you meant prostate cancer, so for folks trying to answer, keep in mind it's prostate!
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Old 05-20-2011
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Quote:
Originally Posted by heights View Post
I think its 3. because prostate cancer's have ducts, so mets to the bone should look the same. Please tell us the answer

Also, the title of you posts says "pancreatic cancer" when you meant prostate cancer, so for folks trying to answer, keep in mind it's prostate!
We apologize for the mistake, the thread has been retitled by USMLE Forums Staff, now it's corrected.

-
-
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Old 05-28-2011
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Quote:
Originally Posted by heights View Post
I think its 3. because prostate cancer's have ducts, so mets to the bone should look the same. Please tell us the answer

Also, the title of you posts says "pancreatic cancer" when you meant prostate cancer, so for folks trying to answer, keep in mind it's prostate!
I also think this is 3. PLEOMORPHIC

I think that word sort of gives it away.
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Old 05-28-2011
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I think is Answer 3 as well...

The other makes me thing on different things, like
1. MM
2. Squamous cell ca.
4. small blue ewing scarcoma
5. I was thinking something like paget disease, but dont know i still maybe wrong, on this.

Either way, i stays with 3... =p
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Old 05-28-2011
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I found this in this forum:
Osteoblastic Verterbral Metastasis

and "doctorF" explained the answer C

here is a paper about this topic, with pics.
Bone histology at autopsy.pdf
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Old 05-28-2011
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Quote:
Originally Posted by bebix View Post
I found this in this forum:
Osteoblastic Verterbral Metastasis

and "doctorF" explained the answer C

here is a paper about this topic, with pics.
Attachment 1339
Ty!!! so my approach was right! .. even why i didnt choose the others one... Im glad ty!

Quote:
"DoctorF says:"C- this is adenocarcinoma of prostate gland... prostate gland cancer metastasizes to vertebrae via the venous plexus around it... B is keratin pearls of squamous cell cancer so cant be it, D is basophil u can never find a basophil in cancer, E is uniform cells, cancer is never uniform cells, they are anaplastic cells, A is agrregates of plasma cell and plasma blasts this feature is of multiple myeloma
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Old 12-29-2014
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Quote:
Originally Posted by meka View Post
What will the histological picture of metastatic osteoblastic increase in bone be? (in prostate cancer)
1. aggregates of plasma cells and plasmablasts
2. nests of epithelial cells joined by bridges and containing keratin pearls
3. plemorphic epithelial cells forming duct-like structures
4. sheets of small blue cells
5. sheets of uniform cells divided into lobules with thin fibrous septa and intervening lymphocytes
I had the NBME and It says that number five is wrong
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