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Old 05-16-2011
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Virus The management of an asymptomatic CMV positive baby

The serum of a newborn infant reveals a 1:32 cytomegalovirus (CMV) titer. The child is clinically asymptomatic. Which of the following courses of action would be advisable?

a. Repeat the CMV titer immediately
b. Wait 6 months and obtain another titer on the baby
c. Obtain a CMV titer from all siblings
d. Obtain an anti-CMV IgM titer from the mother
e. Obtain an anti-CMV IgM titer from the baby
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Old 05-16-2011
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I think i'd go for E) Obtain an anti-CMV IgM titer from the baby

Because Maternal Anti CMV-IgG would be found in the newborn anyway, so you can check if the infection is present in the newborn.
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Old 05-17-2011
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The answer is E.

Clinical manifestations of cytomegalovirus (CMV) infection may not be readily apparent at birth. Thus, in a newborn infant with a 1:32 titer of CMV, it is necessary to determine whether the antibodies were passed transplacentally from the mother (these antibodies would be IgG) or produced by the fetus in response to an in utero infection (IgM).
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