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Old 06-28-2014
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Default Congenital Adrenal Hyperplasia!

Hello,

Does anyone have an easy way to remember the congenital adrenal hyperplasias?

I always tend to mix them up :/
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Old 04-24-2016
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Default CAH

I MISS being 21, when I was WASTED and having LOTS OF SEX.

MISS 21 - WASTED, LOTS OF SEX

Deficient 21 hydroxylase -> Salt wasting (lack of mineralocorticoids (aldosterone)), Excess Sex hormones (precocious puberty/virilization)

17 y/o's are SALTY b/c they're TOO YOUNG FOR SEX

Deficient 17 hydroxylase --> Excess mineralocorticoids (salty), no sex hormones (too young for sex)

Lacking cortisol in all.
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Old 04-25-2016
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Default

Quote:
Originally Posted by usmle2016cc View Post
I MISS being 21, when I was WASTED and having LOTS OF SEX.

MISS 21 - WASTED, LOTS OF SEX

Deficient 21 hydroxylase -> Salt wasting (lack of mineralocorticoids (aldosterone)), Excess Sex hormones (precocious puberty/virilization)

17 y/o's are SALTY b/c they're TOO YOUNG FOR SEX

Deficient 17 hydroxylase --> Excess mineralocorticoids (salty), no sex hormones (too young for sex)

Lacking cortisol in all.
Easier way is to remember that the first number stands for mineralocorticoids and the second number stands for the sex hormones. Think of number one as an arrow pointing up (as in increased).

So in 17 deficiency, first number is one (arrow pointing up) so high mineralocorticoids and low sex hormones. In 21, low mineralo, high sex. In 11, two arrows pointing up, high mineralo, high sex. You can reason out the manifestations yourself once you have the hormone levels.
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