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Old 05-18-2011
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Question Hyperlipidemia Vitamin A toxicity!

In chronic cases of Vitamin A toxicity, hyperlipidemia results. Does anyone here know the exact mechanism behind it?
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Old 05-19-2011
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What is your reference for that fact?
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Old 05-19-2011
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I tried to find a mechanism for chronic toxicity of Vitamin A, but did not find a definitive source. UptoDate lists chronic toxicity symptoms of Hyperlipidemia, hepatotoxicity, alopecia, ataxia, visual impairments, + other non-specifics.

Here is my take though:

Vitamin A is stored in stellate/ito cells in the liver, which also store fat. Chronic excess of Vitamin A may somehow damage these cells and lead to release of fat leading to fatty liver and increased lipid release, thus hepatotoxicity and hyperlipidemia.

Hope that helps
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Old 05-21-2011
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Quote:
Originally Posted by mary View Post
What is your reference for that fact?
From UW explanation in a biochemistry question.
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