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Old 07-03-2014
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Default NBME 11: Immunology

A previously healthy 6 yr old boy develops barking cough and fever.He has not received any immunizations..His leukocyte count is 30,000(70% lymphocyte).Neutrophil chemotaxis and oxidative metabolism are defective due to increased activity of which enzymes?

1.Phospholipase C
2.Protein kinase C
3.Myeloperoxidase
4.NADPH oxidase
5.Adenly cylase


Can someone help me with the answer???
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Old 07-04-2014
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Quote:
Originally Posted by hope2015 View Post
A previously healthy 6 yr old boy develops barking cough and fever.He has not received any immunizations..His leukocyte count is 30,000(70% lymphocyte).Neutrophil chemotaxis and oxidative metabolism are defective due to increased activity of which enzymes?

1.Phospholipase C
2.Protein kinase C
3.Myeloperoxidase
4.NADPH oxidase
5.Adenly cylase


Can someone help me with the answer???
They are talking about Pertussis, recall that the toxin "disables" Gi receptors, leading to increased cAMP and thus, increased adenyl cyclase
hope this helps.
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Old 07-04-2014
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thanks a lot pishoI get it now..I was thinking abt Croup caused by paramyxovirus...i never knew there will be barking cough in pertusis....How was ur exam experience...what kind of questions did u face
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