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6K views 6 replies 3 participants last post by  pshant88 
#1 ·
A 25 year old female patient presented with fatigue
Peripheral blood film showed this

Product Purple Textile Organism Font

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What cell markers are seen on these cells?
a- CD4
b- CD8
c- CD21
d- CD15
e- CD14
 
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#5 ·
Hi Sarah, I'm still not clear about this one. From what I read EBV binds to Cd21 and that's how it infects the B-cells that later then trigger the T-cell CD8 reaction that attacks the infect B-cells. So shouldn't the markers of the cells in the pic be the ones that are found on the B-cells (Cd21)??
 
#6 ·
Reactive lymphocytes are T lymphocytes, not B lymphocytes.
This is the story in any viral infection it's just has a fancy name in EBV infection.
B lymphocytes act as Ag presenting cells pulling viral peptides up to MHC class I molecule on the surface that would then get recognized by CD8 cells and that's why CD8 cells get proliferated (immune response).
 
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