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Old 11-29-2009
Sarah-cali's Avatar
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RBC 25 Year Old with fatigue

A 25 year old female patient presented with fatigue
Peripheral blood film showed this

25 Year Old with fatigue-bloodfilm.jpg
click image to enlarge

What cell markers are seen on these cells?
a- CD4
b- CD8
c- CD21
d- CD15
e- CD14
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Old 11-29-2009
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this is infectious mononucleosis
So I choose CD21 as the correct answer
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Old 11-30-2009
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The blood film is showing Downey cells which are characteristic for mono, so i think cd21 is the right answer.
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Old 11-30-2009
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Arrow Answer to the question

Yeah, these are atypical lymphocytes Downey cells with Ballerina skirt but the correct answer is not CD21, It's CD8. EBV attacks B cell first but then it causes proliferation of T cells
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Old 11-30-2009
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Hi Sarah, I'm still not clear about this one. From what I read EBV binds to Cd21 and that's how it infects the B-cells that later then trigger the T-cell CD8 reaction that attacks the infect B-cells. So shouldn't the markers of the cells in the pic be the ones that are found on the B-cells (Cd21)??
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Old 12-01-2009
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Quote:
Originally Posted by HouseWannabe View Post
Hi Sarah, I'm still not clear about this one. From what I read EBV binds to Cd21 and that's how it infects the B-cells that later then trigger the T-cell CD8 reaction that attacks the infect B-cells. So shouldn't the markers of the cells in the pic be the ones that are found on the B-cells (Cd21)??
Reactive lymphocytes are T lymphocytes, not B lymphocytes.
This is the story in any viral infection it's just has a fancy name in EBV infection.
B lymphocytes act as Ag presenting cells pulling viral peptides up to MHC class I molecule on the surface that would then get recognized by CD8 cells and that's why CD8 cells get proliferated (immune response).
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Old 07-11-2013
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i know this is a really old thread but you can see the darkness on the edges of the cell as it comes into contact with RBCs which is characteristic of CD8 T cells
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Tags
Blood-Films, Hematology-, Immunology-, Microbiology-, Micrographs-, Pathology-, Step-1-Questions

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