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  #1  
Old 05-22-2011
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Biochemistry Vit B3 deficiency and alcohol metabolism!

A patient with untreated pellagra and carcinoid syndrome volunteers for a study on the metabolism of alcohol. Which of the following results do you expect to find in this patient?

A. Increased rate of ethanol formation
B. Increased rate of acetaldehyde formation
C. Increased rate of acetate formation
D. Decreased rate of acetaldehyde formation
E. All of the above
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  #2  
Old 05-22-2011
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Default d decreased rate of acetaldehyde formation

since he's a niacin deficent he cannot dehydrogenate alcohol as it requires nad+ as it is derived from niacin..correct me if i am wrong..thanks in advance
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Old 05-22-2011
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I would go with D. there is no NAD for the alcohol metabolism pathway.
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Old 05-22-2011
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i think its D coz no niacin for NAD
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Old 05-23-2011
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Bravo you've all got the right Answer

The correct answer is D.

In untreated pellagra, niacin levels are low. Niacin is the precursor for NAD+, which is required for alcohol dehydrogenase and acetaldehyde dehydrogenase to function.
In the case of this patient, then, the rate of acetaldehyde synthesis should be decreased and the rate of acetate synthesis should be decreased as well
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