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Old 07-09-2014
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Default trazodone v.s. SSRIS

why does one cause sexual dysfunction and the other priapism when they both function to inhibit serotonin reuptake???

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Old 07-09-2014
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You should remember that these drugs don't just act on serotonin receptors.

Trazodone causes priaprism through antagonism of the alpha adrenergic receptors. So even though it's action is primarily on the serotonin receptors, it acts on other receptors as well.

With SSRIs causing sexual dsf(x)n, this is purely due to it's action on serotionin (it's very specific for serotonin unlike trazodone) --> which is associated with sexual side effects.
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Dr.ann (07-10-2014)


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