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Old 05-26-2011
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Microscope Laminated Concentric Calcific Spherules!

During pelvic examination of a 30 y/o woman, a 12 cm adnexal tumor is detected. Gross examination of a surgical specimen demonstrates a multiloculated cystic cancer. On microscopic examination, laminated, small, concentric and calcific spherules are seen within the tumor.
In addition to being found in this patient's cancer, these structures can also be found in certain cancers arising from which of the following organs?


A. Colon
B. Seminal vesicles
C. Spleen
D. Stomach
E. Thyroid gland
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Old 05-26-2011
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Description of calcifications is of Psammoma Bodies

The three cancers with Psammoma bodies are:

1) Papillary Carcinoma of Thyroid
2) Serous Cystadenocarcinoma of Ovary
3) Meningiomas in CNS

Therefore answer is E) Thyroid gland

Last edited by apx85; 05-26-2011 at 05:34 PM.
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Old 05-26-2011
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Correct Answer Correct Answer: E

Correct Answer: E

Exactly, That's Psammoma Bodies. But sorry, there's an error there, you dont see it at Oligodendrioma of CNS. On Oligodendrioma you see FRIED EGG appearance and you may see calcifications. ( Round nuclei with clear cytoplasm ).

But, on Psammoma bodies you see "Spindle cells concentrically arranged in whorled pattern: which is the definition of Psammoma Bodies ( Laminated calcification )

You missed, Mesotheliomas.

1) Papillary Adenocarcinoma of Thyroid
2) Serous Cystadenocarcinoma of Ovary
3) Meningiomas
4) Malignant Mesothelioma
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YES, the correct answers is E)

for more psammoma bodies, check this video:


and here is a good mnemonic:
Psammoma Bodies

and here the histology of oligodendroglioma:

Last edited by bebix; 05-26-2011 at 05:38 PM. Reason: link
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Old 05-26-2011
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Quote:
Originally Posted by rulz View Post
Correct Answer: E

Exactly, That's Psammoma Bodies. But sorry, there's an error there, you dont see it at Oligodendrioma of CNS. On Oligodendrioma you see FRIED EGG appearance and you may see calcifications. ( Round nuclei with clear cytoplasm ).

But, on Psammoma bodies you see "Spindle cells concentrically arranged in whorled pattern: which is the definition of Psammoma Bodies ( Laminated calcification )

You missed, Mesotheliomas.

1) Papillary Adenocarcinoma of Thyroid
2) Serous Cystadenocarcinoma of Ovary
3) Meningiomas
4) Malignant Mesothelioma

Thanks for the correction rulz!!
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Old 05-27-2011
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Always , Keep it up!
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