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Old 05-26-2011
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Help Adreno-genital syndrome

can someone just explain to me in clear terms, i didnt undetstand goljan's explanation. thanks.
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Old 05-27-2011
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Quote:
Originally Posted by saintdizzy View Post
can someone just explain to me in clear terms, i didnt undetstand goljan's explanation. thanks.
What you did not understood exactly? I can say some words about mechanism:

Look at the picture above (from my notes http://deyneko.com/forum/index.php ). This condition leads to deficiency of production CORTISOL. You know that cortisol has negative feedback to adrenocorticotropic hormone. If there is absence the negative feedback (by cortisol) ACTH tries to stimulate adrenal glands to produce cortisol. In the other words a body doesn't see enough cortisol -> forces to produce it by ACTH in adrenal glands. But there is a problem... Production of cortisol is impossible due to abnormalities (congenital) and the body does NOT know it. In same time adrenocorticotropic hormone forces to work ALL adrenal gland (all three layers). And look again at the picture. In the middle cortisol can not be produced due to a defect but active components/ hormones from zona glomerulosa and zona reticularis can be produced. And those components from zona glomerulosa and zona reticularis produce in excessive amount because ACTH forces to work adrenal glands more and more. So it is not very difficult to imagine if for example girl has excessive amount of active components from zona reticularis... Can you?

Hope it help you...

Other detals you can read here:
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001448/
http://en.wikipedia.org/wiki/Congeni...al_hyperplasia
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Instead of saying “we don’t know why,” though, say “idiopathic.” It sounds so much smarter.
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Old 05-27-2011
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I'd just like to add that its most commonly due to a deficiency of 21 alpha hydroxylase which is responsible for production of aldosterone, corticosterone and cortisol from progesterone. SInce this enzyme is not present, the excess progesterone which accumulates is going to be used for the production of adrenal androgens, DHEA, Androstenedione and testosterone. This would lead to such effects as virilization and hypotension.
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