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Old 05-27-2011
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Heart Why serotonin causes fibrosis of mitral valve in carcinoid syndromes?

hi can anyone explain me plzz, that why serotonin causes fibrosis of the heart valves especially in carcinoid tumours...
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Old 05-27-2011
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I don't remember reading the explanation anywhere. I even tried searching the internet. Maybe we're just supposed to cram it.
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Old 05-27-2011
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Quote:
Originally Posted by yasirsattar75 View Post
hi can anyone explain me plzz, that why serotonin causes fibrosis of the heart valves especially in carcinoid tumours...
Please read the following paper (paragraph about the pathogenesis of 5-HT & valves = highlighted with yellow)
5HT_1.pdf

and also, here is more about 5-HT and valves
Serotonergic Drugs and Valvular Heart Disease (full text)
http://www.ncbi.nlm.nih.gov/pmc/arti...9/?tool=pubmed

Last edited by bebix; 05-27-2011 at 08:37 PM.
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Old 05-31-2011
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Serotonin is mainly metabolized to 5-HIAA, chiefly by the liver. Metabolism involves first oxidation by monoamine oxidase ( MAO ) to the corresponding aldehyde. This is followed by oxidation by aldehyde dehydrogenase to 5-HIAA, the indole acetic acid derivative.

The latter is then excreted by the kidneys. One type of tumor, called carcinoid, sometimes secretes large amounts of serotonin into the blood, which causes various forms of the carcinoid syndrome of flushing, diarrhea, and heart problems. Because of serotonin's growth promoting effect on cardiac myocytes, persons with serotonin-secreting carcinoid may suffer a right heart (tricuspid) valve disease syndrome, caused by proliferation of myocytes onto the valve.


Hope this helps
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Cardiovascular-, Pathology-, Pharmacology-, Physiology-

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