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  #1  
Old 05-29-2011
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Microscope Can you diagnose this picture #2?

Based on the next picture, which of the following diseases is more likely?

Can you diagnose this picture #2?-cell.jpg
click image to enlarge

A) Multiple myeloma
B) Hodgkin's lymphoma
C) Non-Hodgkin's lymphoma
D) Mononucleosis
E) Lupus erythematosus
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  #2  
Old 05-29-2011
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i suck big time at pictures which is a big problem...but i am pretty sure that is a Reed-Sternberg cell, so I'll go with Hodgkin's Lymphoma
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  #3  
Old 05-29-2011
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I agree

Hodgkins Disease
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  #4  
Old 05-29-2011
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Clearly we see Reed-Sternberg Cell, Hodgkin's lymphoma.

RS = Binucleate or bilobed with 2 halves ( owl eyes ) they are CD15/CD30 b cell origins.
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Old 05-30-2011
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100 percent reedstern cell.. hodgkins
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  #6  
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Default hodgkin

its very obvious.. that's Reed-Sternberg (RS) cell. it looks like owl's eye..
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Quote:
Originally Posted by Kelvin View Post
its very obvious.. that's Reed-Sternberg (RS) cell. it looks like owl's eye..
Exactly!
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its 100% Hodgkin's disease....Reed sternberg cell with large inclusion like nucleoli and abundant cytoplasm.
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Old 05-30-2011
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Correct Answer Correct answer.

YES. The correct answer is B) Hodgkin's lymphoma
Can you diagnose this picture #2?-screen-shot-2011-05-30-9.11.09-am.png
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  #10  
Old 05-30-2011
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yes those r RS cells,bt how r MONONUCLEOSIS intranulear inclusions?
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Quote:
Originally Posted by sana akbar View Post
yes those r RS cells,bt how r MONONUCLEOSIS intranulear inclusions?
Good question!

Yes, the SAME Reed-Sternberg cells may also be found in reactive lymphadenopathy (such as infectious mononucleosis, carbamazepine associated lymphadenopathy) and very rarely non-Hodgkin lymphomas.

But if you have to choose an answer, the likelihood is higher for Hodgkin's lymphoma.

In Hodgkin's lymphoma = pathognomonic

More info:
http://www.medscape.com/viewarticle/586299
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  #12  
Old 05-30-2011
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can you post all the picture slides here?
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Quote:
Originally Posted by sana akbar View Post
can you post all the picture slides here?
which ones?
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Old 05-30-2011
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i mean histo patho slides....
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Quote:
Originally Posted by sana akbar View Post
i mean histo patho slides....
check this website
http://library.med.utah.edu/WebPath/webpath.html
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  #16  
Old 05-31-2011
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Non-Hodgkin's lymphoma
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@ethan11, the correct answer is B) Hodgkin's lymphoma
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Old 05-31-2011
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@ Sana....In mononucleosis we have atypical lymphocytes..they look completely different from the classic "owl eye" inclusions of Hodgkins lymphoma

correct me if i'm wrong please.thanks
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Old 05-31-2011
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Quote:
Originally Posted by kiki View Post
@ Sana....In mononucleosis we have atypical lymphocytes..they look completely different from the classic "owl eye" inclusions of Hodgkins lymphoma

correct me if i'm wrong please.thanks
In Mono we can see the SAME Reed-Sternberg cells and also other atypical lymphocytes, like this pic:

Can you diagnose this picture #2?-screen-shot-2011-05-31-9.51.38-am.png

Atypical peripheral blood lymphocyte in patient with mononucleosis (indentation of cell membrane, deeply basophilic cytoplasm and enlarged nucleus, several times larger than adjacent erythrocytes)

but if you see Reed-Sternberg cells, the likelihood is higher for Hodgkin's lymphoma.

Last edited by bebix; 05-31-2011 at 06:19 AM.
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  #20  
Old 05-31-2011
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well i guess we have to do what bebix said and

Most likely go for hodgkins lymphoma if its binucleated, and if rest of the history matches it as well.

thanks again!
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Old 05-31-2011
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Quote:
Originally Posted by kiki View Post
well i guess we have to do what bebix said and

Most likely go for hodgkins lymphoma if its binucleated, and if rest of the history matches it as well.

thanks again!
check FA...I have FA 2011...images 27 page I-7
RS = think "Hodgkin's"
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  #22  
Old 05-31-2011
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N WAT is the difference between ,RS cells n intranuclear inclusions of C.M.V?
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  #23  
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Quote:
Originally Posted by sana akbar View Post
N WAT is the difference between ,RS cells n intranuclear inclusions of C.M.V?
Neoplastic hematopathology:
http://books.google.com/books?id=Jex...ovirus&f=false
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Old 05-31-2011
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Awesome pics Bebix! Also guys, I just want to point out that while it's great to be able to recognize pictures, don't get too freaked out is you can't distinguish between all the different pictures because on the USMLE (and in the real world), you will have clinical clues to help you figure it out. For example, the clinical vignette for CMV would look very different from Hodgkin's lymphoma. Our pathology professor always told us not to look at the picture until we knew what we were looking for, or else you just confuse yourself more. Even pathologists get a clinical vignette before they need to make a diagnosis! Just a word of encouragement to everyone
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