Interleukin responsible for Class switching to IgG - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 05-29-2011
USMLE Forums Newbie
 
Steps History: Not yet
Posts: 1
Threads: 1
Thanked 0 Times in 0 Posts
Reputation: 10
Immunology Interleukin responsible for Class switching to IgG

Hey folks,
Which interleukin is responsible for class switching from IgM to IgG. I know IL-4 stimulates IgE and IL-5 stimulates IgA. But what about IgG?

Any insight would be very helpful! THanks!
Reply With Quote Quick reply to this message



  #2  
Old 05-29-2011
Dr_Laura's Avatar
USMLE Forums Guru
 
Steps History: 1+CK+CS
Posts: 499
Threads: 85
Thanked 529 Times in 222 Posts
Reputation: 539
Default

IL4 IgG & IgE
IL5 IgA
__________________
YouTube:
To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts.
Facebook:
To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts.

Reply With Quote Quick reply to this message
The above post was thanked by:
bebix (05-29-2011)
  #3  
Old 05-29-2011
bebix's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 1,357
Threads: 194
Thanked 3,262 Times in 881 Posts
Reputation: 3272
Default

"B cells generate IgA and IgG by a process known as class-switch recombination (CSR), which is initiated when activated CD4+ T cells interact with IgD+B cells. Signalling mediated by CD40 ligand (CD40L) interaction with CD40, together with secretion of the T-cell cytokines interleukin-10 (IL-10) and IL-4, induces the transcription of IgA, IgE or IgG heavy-chain genes. Compared to IgM, these class-switched immunoglobulins have different effector functions, including the ability to neutralize invading pathogens at sites of entry."

http://www.nature.com
Nature Reviews Immunology 6, 255 (April 2006)
Viral immunity: Turning off class switching
Shannon Amoils
Reply With Quote Quick reply to this message
The above post was thanked by:
Claus_CU (05-30-2011), star123 (05-30-2011)
 
  #4  
Old 05-29-2011
pass7's Avatar
USMLE Forums Guru
 
Steps History: 1+CK+CS+3
Posts: 406
Threads: 30
Thanked 141 Times in 109 Posts
Reputation: 151
Default

i think its IL 4 for IgE
and IL 5 and TGF beta for IgG and IgA
Let me know if i m wrong.
Reply With Quote Quick reply to this message
  #5  
Old 05-30-2011
Dr_Laura's Avatar
USMLE Forums Guru
 
Steps History: 1+CK+CS
Posts: 499
Threads: 85
Thanked 529 Times in 222 Posts
Reputation: 539
Default

Kaplan Immunology says it's IgG and IgE for IL-4 and IgA is IL-5...
__________________
YouTube:
To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts.
Facebook:
To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts.

Reply With Quote Quick reply to this message



Reply

Tags
Immunology-

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
The polymerase responsible for Adenovirus genome replication! struggle USMLE Step 1 Forum 1 05-25-2011 03:12 PM
Which portion of the nephron responsible for fluid absorption aktorque USMLE Step 1 Forum 7 02-17-2011 02:00 PM
The drug class of Metyrapone? Dr. N Elham USMLE Step 2 CK Forum 1 06-13-2010 10:09 AM
Which Neurotransmitter Distrubance is responsible? FreakingOut USMLE Step 1 Forum 2 04-29-2010 11:17 AM
Viral peptides on MHC class II hunath USMLE Step 1 Forum 1 11-16-2009 04:08 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)