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  #1  
Old 05-30-2011
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Question Can you diagnose this blood film picture #4?

Which of the following is a known cause of this anemia?

Can you diagnose this blood film picture #4?-screen-shot-2011-05-30-10.47.34-pm.png
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A) Vitamin B9 deficiency
B) Isoniazid
C) Zinc deficiency
D) Acute Hyperthermia
E) Copper overload

Last edited by bebix; 05-30-2011 at 08:08 PM. Reason: spelling
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Old 05-30-2011
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sideroblastic anemia

B
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Old 05-31-2011
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Ill go with B too, cuz I don know if Zn and Cu def causes any anemia, I dont know if there is any B9. lol
therefore Isoniazid causes B6 def leading to sideroblastic anemia
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Old 05-31-2011
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yup INH causes B6 deficiency and B6 is used in heme synthesis.

glycine + succinyl-CoA in the presence of B6 makes delta-ALA.
therefore no B6----> anemia..specifically sideroblastic anemia
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Old 05-31-2011
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my answer is sideroblastic anemia

@salz...I think Vit B9 is folic acid
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Old 05-31-2011
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Quote:
Originally Posted by Claus_CU View Post
my answer is sideroblastic anemia

@salz...I think Vit B9 is folic acid
oh thanks for the info. i always wondered which number folate was. lol so yes it cant be folate def either cuz folate has hypersegmented nutrophils
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Old 05-31-2011
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Correct Answer correct answer

B) Isoniazid

Sideroblastic anemia

Other causes are:

Drug-induced sideroblastic anemia
- Isoniazid
- Chloramphenicol
- Ethanol
- Cycloserine
Copper deficiency
Lead poisoning
Zinc poisoning
Pyridoxine (Vitamin B6) deficiency
X-linked CONGENITAL SIDEROBLASTIC ANEMIAS (Mutations in the erythroid-specific 5-aminolevulinate synthase (ALAS2) gene)
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Old 05-31-2011
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eeee
striplling RBCs
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Old 05-31-2011
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@dr.muhamad the answer is B)

Basophilic Stippling pictures:

Can you diagnose this blood film picture #4?-screen-shot-2011-05-31-7.23.01-pm.png

Can you diagnose this blood film picture #4?-screen-shot-2011-05-31-7.22.26-pm.png
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  #10  
Old 05-31-2011
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Another pic
Sideroblastic anemia:

Can you diagnose this blood film picture #4?-screen-shot-2011-05-31-7.33.08-pm.png
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