ADP Ribosylation Bacterial Toxins - USMLE Forums
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USMLE Step 1 Mnemonics Mnemonics, acronyms, reminders, and memorizing tips for the USMLE Step 1.


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Old 04-16-2013
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Bacteria ADP Ribosylation Bacterial Toxins

ADP-ribosylation is the addition of one or more ADP-ribose moieties to a protein, a reaction important in cell signaling.
But there are bacterial toxins that act by ADP ribosylation.

Here's the mnemonic
cAMP

c = Cholera (increases cAMP in intestinal cells causing diarrhea), it acts on G-protein

A = Anthrax

M = rotated E = E Coli (heat stable enterotoxin)

P = Pertussis toxin

speaking of the heat labile toxin, let's remember that Labile is just like Air (activates cAMP) while heat stable means stable like ground (activates cGMP)

Note that the cAMP mnemonic above is about ADP ribosylating toxins that work through cAMP activation only. There are 2 more ADB ribosylating bacteria and these are Pseudomonas and Diphtheria toxins both of work on EF-2 factor and inhibit translocation in protein synthesis.
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anthrax toxin doesnt use ADP ribosylation as far as i remember
edema factor itself is adenylate cyclase which produces cAMP
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Quote:
Originally Posted by MedicalExaminer View Post
anthrax toxin doesnt use ADP ribosylation as far as i remember
You don't remember that because it's not mentioned in Kaplan or FA.
But it is an ADP ribosylator.
Check page 132 of this book "Schaechter's Mechanisms of Microbial Disease"

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Quote:
Originally Posted by MedicalExaminer View Post
edema factor itself is adenylate cyclase which produces cAMP
Yeah, you are absolutely right

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according to First Aid- it's Diphtheria toxin, Pseudomonas exotoxin, E. coli HEAT LABILE toxin, Cholera toxin, and Pertussis toxin are the ADP ribosylating toxins. you might need to adjust your explanation.
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Quote:
Originally Posted by bishal View Post
according to First Aid- it's Diphtheria toxin, Pseudomonas exotoxin, E. coli HEAT LABILE toxin, Cholera toxin, and Pertussis toxin are the ADP ribosylating toxins. you might need to adjust your explanation.
Dude, I mentioned all of those in my post!
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Quote:
Originally Posted by Steptectomy View Post
Dude, I mentioned all of those in my post!
you mentioned HEAT STABLE E coli
and not sure on Anthrax
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Quote:
Originally Posted by bishal View Post
you mentioned HEAT STABLE E coli
and not sure on Anthrax
About the Anthrax, I explained to MedicalExaminer above.
About the Heat Stable, I apologize, it was a mistake, you are right.

I guess I totally messed up in this thread
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