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Old 07-23-2011
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Drug Review of Side effects of antiepileptic drugs

Hi everybody. These are most important side effects of AEDs

Carbamazepine: Hyponatremia, ataxia, agranulocytosis, aplastic anemia
Phenytoin: Coarse facial features, ataxia, gingival hyperplasia, lymphadenopathy, hypertrichosis, neuropathy, serum sickness
Valproate: tremor, weight gain, hair loss, pancreatitis, thrombocytopenia
Topiramate: kidney stones, acute myopia and glaucoma, weight loss, CNS symptoms (fatigue, dizziness,...)
Tiagabine: Abdominal pain
Gabapentin: somnolence, ataxia
Oxcarbazepine: hyponatremia, SJS
Lamotrigine: rash, aseptic meningitis
Vigabatrine: vision loss, psychosis, MRI abnormalities
Zonisamide: renal stones, anorexia, in children hyperhydrosis and fever
Phenobarbital /primidone: alteration of sleep wake cycle, hyperactivity
, sedation, behavioral change, tolerance, dependence, dupuytren's contracture
Ethosuximide: Nausea and vomiting, hyperactivity, somnolence.

Phenytoin, phenobarbital, primidone, valproate, carbamazepine, lamotrigine all can cause SJS and TEN

Felbamate: Aplastic anemia
Levetiracetam: infection

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