Biochemical Abnormalities in Various Types of Rickets - USMLE Forums
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  #1  
Old 09-16-2011
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Arrow Biochemical Abnormalities in Various Types of Rickets

Phosphate and Calcium and Vitamin D levels in various types of rickets.

The attached PDF file contains a table that compares the various types of rickets and the expected biochemical abnormalities including serum calcium and phosphorus level.

This table is very high yield and need to be memorized to answer relevant USMLE questions.

The parameters in red font denotes that they are helpful in differentiating one from another.

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File Type: pdf Rickets-phosphate-calcium-levels.pdf (47.0 KB)
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Old 09-16-2011
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Isn't "Vit D resistant rickets" the same as "hypophosphatemic rickets"?
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Old 09-16-2011
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Quote:
Originally Posted by soulhead View Post
Isn't "Vit D resistant rickets" the same as "hypophosphatemic rickets"?
The term vitamin D-resistant rickets (VDRR) originally was used to describe a syndrome of hypophosphatemia and rickets that resembled vitamin D deficiency but did not respond to vitamin D replacement. This disorder is now called hereditary hypophosphatemic rickets with hypercalciuria (HHRH) because the primary problem is phosphate wasting rather than true vitamin D resistance.
By contrast, true vitamin D resistance is characterized by hypocalcemia as well as hypophosphatemia and results from an inherited defect in the calcitriol receptor that limits the interaction with 1,25-dihydroxyvitamin D.
In HHRH, you have normal Calcium level and consequently normal PTH levels. While in VDRR, you have low Ca and consequently secondary hyperparathyroidism (high PTH level).
Another, important diagnostic feature of HHRH, is the high Calcium levels in urine, which is not seen in any other type of rickets.

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Old 09-19-2011
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Help sabio help!!

i cant open the file in readable form..what am i doing wrong???
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Old 09-19-2011
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Quote:
Originally Posted by samstar View Post
i cant open the file in readable form..what am i doing wrong???
Try to save it first to your computer and then open it.

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Old 12-19-2011
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Little more about hypophosphatemic rickets, such a tedious topic. http://emedicine.medscape.com/article/922305-overview
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