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Old 02-15-2010
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Immunology ANA Staining Patterns

The patterns by which antinuclear antibodies stain may give a good diagnostic clue in rheumatological diseases.
This clue is loved by USMLE question writers and it's very important to know the diagnostic significance of each pattern.
Here's a quick review:
  • Rim (Peripheral) Pattern: is very specific for SLE
  • Homogenous Pattern: is also specific for SLE and can be further tested with Anti-dsDNA, Anti-ssDNA, and Anti-Smith.
  • Speckled Pattern: is the most common pattern but it's the least specific is it can be seen SLE, Scleroderma, Sjogren's, Mixed Connective Tissue disease, and also in normal people.
  • Diffuse Pattern: is also non specific
  • Centromere Pattern: is specific for CREST
  • Nucleolar Pattern: is specific for scleroderma and systemic sclerosis
Some other useful threads
p-ANCA c-ANCA causes
Positive Autoimmune Antibodies and Causes
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The above post was thanked by:
a.albulushi (05-22-2013), dinosaur108 (07-12-2012), erickven (01-30-2017), R777 (12-26-2013), Taiwan_Guy (12-04-2010), wahaha007 (02-16-2010)


Immunology-, Internal-Medicine-, Rheumatology-

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