Diabetes + Dermatitis + Anemia - USMLE Forums
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USMLE Step 2 CK Classic Clues Classic clues seen in clinical case scenarios in USMLE Step 2 CK questions.

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Old 05-06-2010
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Thyroid Diabetes + Dermatitis + Anemia

The combination of these three clinical features is a classical presentation of a patient with Glucagonoma.
It's tumor of the alpha cells of the pancreas that produces Glucagon.
Although this tumor is one of the rarist tumors of mankind it's still asked by the USMLE because it implies understanding of the glucagon physiology.
The diabetes is usually mild, the anemia is due to the catabolic action of glucagon, and the dermatitis is characteristically described as Migratory Necrolytic Dermatitis.
Diagnosis is made by elevated glucagon blood level and the tumor is confirmed by CT scan.
Surgery is curative.
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