Unfractionated vs low-molecular-weight heparin - USMLE Forums
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Old 08-12-2016
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Default Unfractionated vs low-molecular-weight heparin

Can someone help clarify what are the indications between these 2 kinds of heparin? Thanks. Iam so confused about how to choose between two.
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Old 03-22-2017
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Originally Posted by vinci_4693 View Post
Can someone help clarify what are the indications between these 2 kinds of heparin? Thanks. Iam so confused about how to choose between two.
Low molecular weight heparin is metabolized by the kidneys, so whenever a patient presents with ESRD, you have to avoid giving them low molecular weight heparin. It can lead to more bleeding.
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Originally Posted by vinci_4693 View Post
Can someone help clarify what are the indications between these 2 kinds of heparin? Thanks. Iam so confused about how to choose between two.
Unfractionated heparin is safe in use for pregnancy as it is too large and negatively charged to cross placenta.
LMWH is not safe to use for pregnancy.

Unfractionated heparin has higher incidence of HIT, LMWH still has risk but is less likely.
When HIT occurs, immediately stop all heparin-based products (UNF and LMWH).

Heparin is generally given to pregnant patients with anti-phospholipid syndrome.
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