Preventing esophagitis after radiotherapy - USMLE Forums
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Old 06-14-2011
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Drug Preventing esophagitis after radiotherapy

what drug is given prophylactically to prevent esophagitis after radiation
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Old 06-14-2011
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sucralfate as i remember
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Old 06-15-2011
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Originally Posted by surg View Post
how does it help? anyone? thanks...
i don t konw if this helps
Unlike the other classes of medications used for treatment of peptic ulcers, sucralfate is a sucrose sulfate-aluminum complex that binds to the hydrochloric acid in the stomach and acts like an acid buffer with cytoprotective properties
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Old 06-16-2011
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ok so any one sure about this
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Old 06-16-2011
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It looks like there is no one perfect answer to prevent radiation-induced esophagitis.

The normal esophageal mucosa undergoes continuous cell turnover and renewal. Acute radiation esophagitis is primarily due to effects on the basal epithelial layer. This causes a thinning of the mucosa, which can progress to denudation.

Acute toxicity is manifested clinically as dysphagia, odynophagia, and substernal discomfort, and usually occurs within two to three weeks after the initiation of RT. Patients may describe a sudden, sharp, severe chest pain radiating to the back. The symptoms of acute radiation esophagitis may be confused with Candida esophagitis, which can occur as a complication of treatment.

Acute esophagitis is managed symptomatically. Treatment measures include:

Topical anesthetics (viscous lidocaine), analgesics (antiinflammatory agents, narcotics), antacid therapy (proton pump inhibitors, H2 receptor blockers), and promotility agents (metoclopramide).

Dietary modification (bland, pureed, or soft foods, soups), to help a patient maintain adequate caloric and liquid intake. Eating more frequent, smaller meals, and avoiding foods that are very hot or very cold may also be useful. Avoidance of smoking, alcohol, coffee, spicy or acidic foods or liquids, chips, crackers, fatty, and indigestible foods can be helpful.

Various chemopreventive agents have been investigated to reduce radiation-induced normal tissue toxicity, although none has an established role in preventing esophageal toxicity.

The best studied of these is amifostine, a free radical scavenger. Amifostine has an established role in preventing some of the acute toxicities associated with radiation therapy in head and neck cancer.

Source: UpToDate
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Gastroenterology-, Oncology-, Radiology-

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