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Old 07-20-2011
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Drug Side effects of seizure meds

A 25 y/o woman was recently diagnosed with partial seizures and started on medication for this condition. After 2 months the patient complains that her coworkers have noted that she has become mentally sluggish. Additionally, the patient was in the ER last weekend with horrible back pain and was diagnosed with a kidney stone. Which of the following is most likely responsible for this patient's symptoms?

A, Benzodiazepines
B. Carbamazepine
C. Lamotrigine
D. Phenytoin
E. Topiramate
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  #2  
Old 07-21-2011
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Topiramate and Zonisamide can cause renal stones
A pearl about Topiramate--> associated with increased risk of oral clefts when used in pregnanct
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Old 07-21-2011
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I think it is E
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Old 07-21-2011
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its e.............
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Old 07-22-2011
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i'll go with e
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Old 07-22-2011
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E. Topiramate cause kidney stone
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Old 07-22-2011
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The correct answer is E. Topiaramate enhances GABA activated chloride channels and inhibits excitatory neurotransmission, through actions on kainate and AMPA receptors. The drug has been linked to short term memory loss and word finding difficulty. Additionally, the drug may cause kidney stones (incidence 1.5%)
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Internal-Medicine-, Neurology-, Pharmacology-, Step-2-Questions

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