Originally Posted by aghammoud85
One of the purpose for PUBS (percutaneous umbilical blood sampling) is to detect IgM antibody. Why do we need to detect IgM antibody? IgM antibody doesn't across placeta, do they? I don't understand its useness.
Thanks in advane!
IgM does not cross the placenta and that's why we have to take a sample directly from the umbilical blood vessels! If it'd cross like IgG, we can detect it in the maternal blood, and btw, IgM means acute infection and it can be severe/ lethal, wheras IgG may be as a result of vaccination or natural immunity to disease and it does not indicate severity.