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USMLE Step 2 CK Forum USMLE Step 2 CK Discussion Forum: Let's talk about anything related to USMLE Step 2 CK exam


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Old 08-09-2011
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Default PUBS

One of the purpose for PUBS (percutaneous umbilical blood sampling) is to detect IgM antibody. Why do we need to detect IgM antibody? IgM antibody doesn't across placeta, do they? I don't understand its useness.

Thanks in advane!
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Old 08-09-2011
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Originally Posted by aghammoud85 View Post
One of the purpose for PUBS (percutaneous umbilical blood sampling) is to detect IgM antibody. Why do we need to detect IgM antibody? IgM antibody doesn't across placeta, do they? I don't understand its useness.

Thanks in advane!
IgM does not cross the placenta and that's why we have to take a sample directly from the umbilical blood vessels! If it'd cross like IgG, we can detect it in the maternal blood, and btw, IgM means acute infection and it can be severe/ lethal, wheras IgG may be as a result of vaccination or natural immunity to disease and it does not indicate severity.
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Old 08-09-2011
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Originally Posted by aghammoud85 View Post
One of the purpose for PUBS (percutaneous umbilical blood sampling) is to detect IgM antibody. Why do we need to detect IgM antibody? IgM antibody doesn't across placeta, do they? I don't understand its useness.

Thanks in advane!
PUBS is done after you have a high bilirubin level on an amnio that is done because the mother is sensitized to RH factor....high billirubin means the fetal is probably anemic so you do pubs and if the HCT is low you can perform a intrauterine transfusion.....
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