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  #1  
Old 08-17-2011
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Post orphan annie

a 30 yrs old man presents with a rapidly enlarging,palpable 2.5 cm nodule ni the thyroid gland .thyroid isotopes demostrate the gland to ne cold.on resection with subsequent pathological examination,the nodule is found to contain follicular structures some of which have niward protuding fibrovascular branching cores covered with epithelium.many of the epithelial cells have the orphan annie nucleus.which of the following is the most likely diagnosis
1)follicular ca of the thyroid
2)graves dsc
3)non toxic goitre
4)papillary ca of the thyroid
5)anaplastic ca of the thyroid
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  #2  
Old 08-18-2011
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Quote:
Originally Posted by samstar View Post
a 30 yrs old man presents with a rapidly enlarging,palpable 2.5 cm nodule ni the thyroid gland .thyroid isotopes demostrate the gland to ne cold.on resection with subsequent pathological examination,the nodule is found to contain follicular structures some of which have niward protuding fibrovascular branching cores covered with epithelium.many of the epithelial cells have the orphan annie nucleus.which of the following is the most likely diagnosis
1)follicular ca of the thyroid
2)graves dsc
3)non toxic goitre
4)papillary ca of the thyroid
5)anaplastic ca of the thyroid
papillary thyroid cancer! I had the same question from kaplan qbook!
the hint is the "protruding fibrovascular branching cores covered with epithelium" which are the papillary projections. Orphan annie is not totally specific for papillary cancer but its a hint too.
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  #3  
Old 08-18-2011
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4)papillary ca of the thyroid from orphan anni
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  #4  
Old 08-18-2011
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Orphan annie is papillary carcinoma
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  #5  
Old 08-18-2011
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Its 4. papillary ca
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  #6  
Old 08-18-2011
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papillary ca
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