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Old 08-31-2011
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Drug Indications of Rituximab

Rituximab is a monoclonal antibody against CD20 it has many uses with different diseases which makes me confused im trying to collect it plz try to add so we can make a good list


1- autoimmune hemolytic anemias: warm and also cold
2- chronic lymphocytic leukemia
3- Non Hodgkin lymphoma
4- Refectory cases of ITP (Idiopathic thrombocytopenic purpura)

Last edited by youssef2310; 08-31-2011 at 01:37 AM.
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Old 08-31-2011
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Default non hodgkin lymphoma

3 is non hodgkin lymphoma
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Old 08-31-2011
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Refectory cases of ITP ( Idiopathic thrombocytopenic purpura)
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Old 08-31-2011
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read it again guys...
it's used in all four, he meant if you think of some other disease add on to list
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Old 08-31-2011
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Hematological neoplastic diseases
Rituximab used to treat hematological neoplasms such as leukemias and lymphomas.The use of rituximab in Hodgkin's lymphoma, including the lymphocyte predominant subtype has been reviewed recently.
In multiple myeloma, treatment with rituximab fails to deplete circulating CD20+ B or plasma cells, even after up to four cycles of treatment; in some patients, rituximab treatment increases the number of circulating CD20+ B cells.
Autoimmune diseases

Rituximab has been shown to be an effective rheumatoid arthritis treatment in three randomised controlled trials and is now licensed for use in refractory rheumatoid disease. In the United States, it has been FDA-approved for use in combination with methotrexate (MTX) for reducing signs and symptoms in adult patients with moderately- to severely-active rheumatoid arthritis (RA) who have had an inadequate response to one or more anti-TNF-alpha therapies.
There is some evidence for efficacy, but not necessarily safety, in a range of other autoimmune diseases, and rituximab is widely used off-label to treat difficult cases of multiple sclerosis, systemic lupus erythematosus and autoimmune anemias. There are significant concerns about progressive multifocal leukoencephalopathy (PML) infection in SLE patients and other conditions.
Other autoimmune diseases that have been treated with rituximab include
1.autoimmune hemolytic anemia,
2.pure red cell aplasia,
3.idiopathic thrombocytopenic purpura (ITP),
4.Evans syndrome
5.vasculitis (for example Wegener's Granulomatosis), bullous skin disorders (for example pemphigus, pemphigoid), type 1 diabetes mellitus, Sjogren's syndrome, and Devic's disease,[14] and thyroid-associated ophthalmopathy.[15]
A new study from Norway suggests that rituximab (together with methotrexate) might help patients with
chronic fatigue syndrome. A clinical trial is ongoing.
Anti-rejection treatment for organ transplants
Rituximab is now being used off-label in the management of kidney transplant recipients. This drug may have some utility in transplants involving incompatible blood groups. It is also used as induction therapy in highly sensitized patients going for kidney transplantation.
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Old 08-31-2011
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Quote:
Originally Posted by busterbee View Post
read it again guys...
it's used in all four, he meant if you think of some other disease add on to list
i think you need to read it again he was compiling the list by editing his original post. originally he had only two and added as we posted. try to think out of the box its not always MCQ when u see a list of 4 or 5 ponits

PS: read the last line of his post which says "last edited"
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