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Old 09-13-2011
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Drug OCP use and reduced risk of cancer?

A 29 years old woman is on OCP for 6 years. The risk of which of the following cancer is most significantly reduced?
1. 1. Cervical cancer.
2. 2. Endometrial cancer.
3. 3. Breast cancer.
4. 4. Liver cancer
5. 5. No significant effect on the risk of any of them.
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Old 09-13-2011
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endometrial ca
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Agree OCPs dec the risk of ovarian & endometrial Ca.
And increase the risk of breast & cervical Ca.
Also associated with hepatic adenomas rarely.
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Last edited by step1an; 09-13-2011 at 11:39 AM.
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Quote:
Originally Posted by step1an View Post
Agree OCPs dec the risk of ovarian & endometrial Ca.
And increase the risk of breast & cervical Ca.
Also associated with hepatic adenomas rarely.
ya ,true..but i wonder how does it do that ?estrogen is responsible for endometrial hyperplasia n i think hyperplasia itself produces endometrial cancer later on..can anyone tell the concept behind it ?
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Quote:
Originally Posted by iron View Post
ya ,true..but i wonder how does it do that ?estrogen is responsible for endometrial hyperplasia n i think hyperplasia itself produces endometrial cancer later on..can anyone tell the concept behind it ?
Agree estrogen alone increases the risk of endometrial hyperplasia and Ca.
There are two types of OCPs; combination estrogen-progesterone & progesterone only pills.
IMO, The main beneficial effects for endometrium come from the progesterone because it counters the proliferative effects of the estrogen.
For Ovaries, I think the anovulation is a protective factor factor preventing Ca.
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d. Endometrial cancer

Explanation: use of the oral contraceptive pill significantly decreases a woman's likelihood of developing endometrial cancer. It also reduces the risk for ovarian cancer. The development of endometrial cancer is due to unopposed estrogen exposure whether endogenously or exogenously ( usually starts as hyperplasia), due presence of progestin, that why OCP provides such protection.
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Quote:
Originally Posted by step1an View Post
Agree OCPs dec the risk of ovarian & endometrial Ca.
And increase the risk of breast & cervical Ca.
Also associated with hepatic adenomas rarely.
i thought they increase the risk of ca breast
n decrease the risk of endometrium n ovaries....
but had no effect cervical carcinoma??
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The protection from endometrial carcinoma from progestins. Estrogen is proliferative hormone as we know, that why is related to hyperplasia & carcinoma (Unopposed estrogen).
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Ocp reduces risk of ovarian and endometrial ca. Also prevents ectopic pregnency. Protection from progesterone part.
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Quote:
Originally Posted by aasiaafzal View Post
i thought they increase the risk of ca breast
n decrease the risk of endometrium n ovaries....
but had no effect cervical carcinoma??
Evidence shows that long-term use of OCs (5 or more years) may be associated with an increased risk of cancer of the cervix (the narrow, lower portion of the uterus) (12). Although OC use may increase the risk of cervical cancer, human papillomavirus (HPV) is recognized as the major cause of this disease.

Sources: http://www.cancer.gov/cancertopics/f...contraceptives
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Old 11-09-2013
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Quote:
Originally Posted by step1an View Post
Agree estrogen alone increases the risk of endometrial hyperplasia and Ca.
There are two types of OCPs; combination estrogen-progesterone & progesterone only pills.
IMO, The main beneficial effects for endometrium come from the progesterone because it counters the proliferative effects of the estrogen.
For Ovaries, I think the anovulation is a protective factor factor preventing Ca.
I learned from lecture that ovaries that are anovulatory stay in the proliferative phase and therefore those patients have higher exposure to endogenous estrogen. This makes me think anovulation is a risk factor, not a protective factor. Please correct if wrong.
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Old 11-11-2013
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let me also explain this guys. i think use of ocp's causes excess estrogen state, excess estrogen stimulates endometrium, causing endometrial hyperplasia and then endometrial cancer. use of ocps is also associated with hepatic adenoma, because estrogen increases the vascularity of liver.
about ocps and ovarian cancer my theory is that use of ocp's causes chronic anovulatory state, and chronic anovulation is a risk factor for cancer of ovaries.
correct me if i am wrong.
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Old 11-28-2013
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Quote:
Originally Posted by step1an View Post
Agree estrogen alone increases the risk of endometrial hyperplasia and Ca.
There are two types of OCPs; combination estrogen-progesterone & progesterone only pills.
IMO, The main beneficial effects for endometrium come from the progesterone because it counters the proliferative effects of the estrogen.
For Ovaries, I think the anovulation is a protective factor factor preventing Ca.

Anovulation cause unopposed estrogenemic state increasing the risking of endometrial hyperplasia and carcinoma.
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it reduces risk of endometrial ca

Last edited by hariomsharma; 06-23-2014 at 12:53 AM. Reason: correction
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Quote:
Originally Posted by ag2011n View Post
d. Endometrial cancer

Explanation: use of the oral contraceptive pill significantly decreases a woman's likelihood of developing endometrial cancer. It also reduces the risk for ovarian cancer. The development of endometrial cancer is due to unopposed estrogen exposure whether endogenously or exogenously ( usually starts as hyperplasia), due presence of progestin, that why OCP provides such protection.
hw does it offer protection for ovarian ca
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