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  #1  
Old 11-09-2011
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Lungs DLCO and Asthma

Why does DLCO increease in asthma?
I read that it can be normal too....

Can someone please explain the mechanism?
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  #2  
Old 11-09-2011
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I don't know why it might be high in Asthma but have a look here
DLCO Diffusion Capacity of the lungs for Carbon Monoxide
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Old 11-10-2011
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Quote:
Originally Posted by zebra85 View Post
I don't know why it might be high in Asthma but have a look here
DLCO Diffusion Capacity of the lungs for Carbon Monoxide

Ya...I saw that...but it doesnt explain why it is normal or increased. I guess it is not that high yield then.

Thanks for the post anyways.
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Old 11-10-2011
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Kaplan vids mentioned that DLCO is normal in asthma or copd, increased in bleeding (eg good pastures syndrome) and decreased in restrictive lung disease and emphysema..in the case of normal DLCO you should proceed with bronchodilator reversibility test to differentiate between the two (asthma vs copd). Hope that helps!
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Old 08-14-2013
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could anyone give an explanation why DLco increases in asthma (MTB2) vs being normal (kaplan)
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Old 08-14-2013
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Default hi

i think that since asthama is a obstructive airways disease, so very less part of the co is exhaled and hence the volume of co available for diffusion is more and hence DLco increses
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Old 08-14-2013
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BC in Asthma and COPD you have bronchial problem - spasm, obstruction...
But alveoles are fine!!!

I had exact same question a while ago
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Old 08-14-2013
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Quote:
Originally Posted by medico one View Post
i think that since asthama is a obstructive airways disease, so very less part of the co is exhaled and hence the volume of co available for diffusion is more and hence DLco increses
CO when inhaled it hardly can be exhaled cause almost all of it binds Hb
so if u want to increase DLco u should increase Hb concentration in lungs as far as i understand

thats what wiki gives:
Increase[edit source | editbeta]

Factors that can increase the DLCO include polycythaemia, asthma (can also have normal DLCO) and increased pulmonary blood volume as occurs in exercise or congestive heart failure. Other factors are right-to-left pulmonary shunting that occurs in left heart failure, and alveolar hemorrhage.[4]

maybe its not a big deal but still feel crappy when cant figure out the mechanism behind this
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Old 03-06-2014
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Default increase DLCO in asthma vs copd

increase in DLCO in asthma is due to increase in blood volume in capillary bed due to congestion in lungs , however it may not always be present due to irregularity in ventilation perfusion in lung which may decrease the effect of increase in blood volume

whereas in COPD there is a decrease in DLCO primerly due to decrease in capillary bed due to alveolar wall destruction and also due to ventilation perfusion mismatch
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Old 02-10-2015
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Thanks for this reply, it makes sense!
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Old 05-24-2016
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Smile Reasons for why does DLCO increease in asthma?

Factors that can increase the DLCO include asthma and increased pulmonary blood volume as occurs in exercise. Other factors are left to right intracardiac shunting and alveolar hemorrhage.
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