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  #1  
Old 03-01-2010
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Liver Drug precipitating Hepatic Encephalopathy

Excessive use of which drug may precipitate hepatic encephalopathy and why ..
a. Metoprolol
b. enalapril
c. furosemide
d. cholcine
e . PPI
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  #2  
Old 03-01-2010
Ryuunosuke
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Default PPI is the answer

As far as I know that PPI are associated with SBP (spontaneous bacterial peritonitis) this in turn may precipitate hepatic encephalopathy.
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  #3  
Old 03-01-2010
Ryuunosuke
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Default cholcine?

What is chocine by the way?
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Old 03-01-2010
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Colchine used in gout ..
Its true PPI may worsen SBP .... Thanks for that coz i forgot that ..
But its not PPI ....
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Old 03-01-2010
Ryuunosuke
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Default

Quote:
Originally Posted by FSUSTC View Post
Colchine used in gout ..
Its true PPI may worsen SBP .... Thanks for that coz i forgot that ..
But its not PPI ....
So you mean Colchicine not colchine
If PPI is not the answer then what is it? Please tell me
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Old 03-01-2010
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sorry for that .. yes its colchicine
Ans is furosemide ....but Why ??
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Old 03-01-2010
Ryuunosuke
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Default

Quote:
Originally Posted by FSUSTC View Post
sorry for that .. yes its colchicine
Ans is furosemide ....but Why ??
Really I don't know, that's a good question. Let's see if somebody can answer it for us here
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Old 03-01-2010
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Default

Quote:
Originally Posted by FSUSTC View Post
Colchine used in gout ..
Its true PPI may worsen SBP .... Thanks for that coz i forgot that ..
But its not PPI ....
How about frusemide ?
IS that the drug which can coz changes in K level in bloob ?
I think changes in K level in blood could precipitate encephalopathy.
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  #9  
Old 03-02-2010
Ryuunosuke
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Embarrassed

Quote:
Originally Posted by wahaha007 View Post
How about frusemide ?
IS that the drug which can coz changes in K level in bloob ?
I think changes in K level in blood could precipitate encephalopathy.
What is the mechanism by which hypokalemia causes hepatic encephalopathy!?
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Old 03-02-2010
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Default More ammonia in alkalosis

Quote:
Originally Posted by Ryuunosuke View Post
What is the mechanism by which hypokalemia causes hepatic encephalopathy!?
The hypokalemia and metabolic alkalosis seen with any diuretic therapy (except K+ sparing) will favor the conversion of NH4+ to NH3 thereby contributing to more ammonia formation and worsening or precipitating the encephalopathy.
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Old 03-02-2010
Ryuunosuke
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Smile woow

Quote:
Originally Posted by Sarah-cali View Post
The hypokalemia and metabolic alkalosis seen with any diuretic therapy (except K+ sparing) will favor the conversion of NH4+ to NH3 thereby contributing to more ammonia formation and worsening or precipitating the encephalopathy.
Woow, thank you for the explanation
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Old 03-02-2010
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Dehydration , infection , electrolyte abnormality ( decre.K+ & increa HCO3-), sedative , GI bleeding = all of this condition worsen encephalopathy ...
In cirrhosis diuretics is used for edema and ascitis , so if it used excessively for edema ,it may cause dehydration and elec abnormality which worsen encephalopathy .......
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