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Old 11-20-2011
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Question The pathophysiology of edema & hypertension in hyperaldosteronism

Hi all:

In FA for CK p. 129 says that Conn syndrome patients have " diastolic hypertension without edema." But why it is " diastolic" hypertension and why there is no edema? In my opinion, due to too much aldosterone, our body absorbs too much water so there is increased preload and thus there is systolic hypertension plus edema.

Please help me explain this,

thank you!
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Old 11-20-2011
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Well for the edema , the reason is believed due to sodium escape phenomenon which is related to increased levels of Atrial natriuretic peptide.
but the reason of why it affects the diastolic only i actually don't know tge mechanism of that.
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Old 01-23-2012
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Here is my understanding of it , mostly from Goljian.

Aldosterone causes Na retension with subsequent increase in Blood volume and pressure. ANP secretion is stimulated which restores blood volume via naturesis.
Goljian also escapes this escape phenomenon as a result of decrease tubular reabsorption of Na and water dt increase cappillary hydrostatic pressure
( there was hypertension right!!) he talks about it in the audio.
As a result the blood volume is almost restored, and systolic bp almost normal.
The diastolic HTN is explained by increase Na in blood which diffuses into arteriolar smooth muscle stim Ca release and contraction so increase TPR and diastolic pressure.

Hope this helps, plz add to that if you can
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Old 01-23-2012
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Quote:
Originally Posted by chienpolska View Post
Hi all:

In FA for CK p. 129 says that Conn syndrome patients have " diastolic hypertension without edema." But why it is " diastolic" hypertension and why there is no edema? In my opinion, due to too much aldosterone, our body absorbs too much water so there is increased preload and thus there is systolic hypertension plus edema.

Please help me explain this,

thank you!
i think diastolic HT due to angiotensin2. potent vasoconstructor. inc PVR ,
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