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Old 01-16-2012
tyagee's Avatar
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Drug ACEI decreases pulse pressure?

Any idea why angiotensin converting enzyme inhibitors decrease the pulse pressure?

They are effective vasodilators...that means they decrease TPR...aka DBP...that should increase Pulse pressure...

Please reply why they decrease pulse pressure?
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Old 01-18-2012
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I guess

When ACEI acts the V.D they lead to decrease both afterload

which means systolic pr decreases

since pulse pr = systolic pr - diastolic pr
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Old 01-18-2012
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ACE inhibitors decrease systolic and diastolic pressures. But they decrease the systolic more than the diastolic so therefore they decrease the pulse pressure.

For example, patient has 160/100 you give ACEI, now he's 120/90 so you decreased the pulse pressure from 40 to 30.

This property of ACEI is not seen with other antihypertensive and it's really good effect, because increased pulse pressure has been found to be related to accelerated aging of blood vessels (stiffness).

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Old 01-18-2012
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Quote:
Originally Posted by mary View Post
ACE inhibitors decrease systolic and diastolic pressures. But they decrease the systolic more than the diastolic so therefore they decrease the pulse pressure.

For example, patient has 160/100 you give ACEI, now he's 120/90 so you decreased the pulse pressure from 40 to 30.

This property of ACEI is not seen with other antihypertensive and it's really good effect, because increased pulse pressure has been found to be related to accelerated aging of blood vessels (stiffness).

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thanks. nice explanation only if you can tell the source i can accept. thanks once again.
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