Hereditary Spherocytosis Question - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 2 CK Forum

USMLE Step 2 CK Forum USMLE Step 2 CK Discussion Forum: Let's talk about anything related to USMLE Step 2 CK exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 01-05-2016
USMLE Forums Newbie
 
Steps History: Step 1 Only
Posts: 7
Threads: 1
Thanked 0 Times in 0 Posts
Reputation: 10
Smile Hereditary Spherocytosis Question

For my understanding, HS will cause RBC trapped in the spleen and destructed. I understand why it has higher MCHC.
My question is whether the iron workup will show low iron and low ferritin and lower mcv?
thanks, guys
Reply With Quote Quick reply to this message



  #2  
Old 01-06-2016
USMLE Forums Addict
 
Steps History: Not yet
Posts: 106
Threads: 1
Thanked 51 Times in 36 Posts
Reputation: 61
Default HI

All hemolytic anemia's will have normal MCV. Unless there is a concurrent folate or B12 deficiency (increased MCV) or iron deficiency (low MCV). All hemolytic anemias can have normal ferritin and normal iron. During an acute hemolytic episode these values can be low.
Reply With Quote Quick reply to this message
  #3  
Old 01-06-2016
USMLE Forums Scout
 
Steps History: Not yet
Posts: 50
Threads: 3
Thanked 23 Times in 16 Posts
Reputation: 33
Default

Well, not all hemolytic anemias are normocytc. Hemolytic anemias present with high RI ( more than 2). Reticulocyte has MCV between 103 - 126, so if your reticulocytosis is high enough you can have elevated MCV on CBC due to high amount of reticulocytes that will drag the average to macrocytic range.( => Macrocytic nonmegaloblastic anemia)
Remember that some microcytic/macrocytic anemia have 2 mechanism of decreased RBC. For example, B12 def pt has low RBC due to ineffective erythropoesis due do inability do synthesize DNA, also they have hemolysis.
Reply With Quote Quick reply to this message
  #4  
Old 01-07-2016
USMLE Forums Addict
 
Steps History: Not yet
Posts: 106
Threads: 1
Thanked 51 Times in 36 Posts
Reputation: 61
Default You are correct

You are correct. But I was trying to simplify things for the the step 2 ck.
Reply With Quote Quick reply to this message



Reply

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
MCHC increased in hereditary spherocytosis hola! USMLE Step 1 Forum 1 12-24-2014 06:01 AM
Hereditary Hemochromatosis StateoftheArt USMLE Step 1 Forum 0 05-21-2014 11:48 AM
Hereditary spherocytosis AhmedReda USMLE Step 1 Forum 2 03-28-2014 10:28 AM
Relation between Spherocytosis and High Oncotic pressure??? agabozy USMLE Step 2 CK Forum 3 02-11-2013 11:12 AM
hereditary nonpolyposis colorectal cancer doctorF USMLE Step 1 Forum 15 07-27-2010 04:13 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)