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Old 02-18-2016
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Post NBME 6- Section 2 Q 40

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Old 02-18-2016
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The neutrophil uses cell adhesion molecules called L-selectin to loosely attach itself to the endothelial lining of the blood vessel.L-selectin adhesion molecules undergo constant turn over as it moves long the blood vessel. As L-selectin is removed from the cell surface by the enzyme sheddase, it is replaced by newly produced L-selectin from within inside the neutrophil.Glucocorticoids are known to decrease gene transcription of L-selection thereby decreasing the amount produced and transferred to the surface to replace recently shed L-selectin. Without this replacement, the neutrophil will detach (or undergo "demargination") to then enter into the circulatory compartment.
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