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Old 04-15-2012
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Thyroid Effect of estrogen on TBG

What is the mechanism of increased production of TBG in pregnancy?
It was aan easy step 1 concept, but I am have trouble recalling the easiest things while studying for CK
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Old 04-17-2012
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Estrogen increases the production of TBG. In effect, total T3 + T4 will increase but the free levels of T3 + T4 stay the same: The patient remains euthyroid.
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Old 04-17-2012
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Quote:
Originally Posted by add1 View Post
Estrogen increases the production of TBG. In effect, total T3 + T4 will increase but the free levels of T3 + T4 stay the same: The patient remains euthyroid.
i think opposite effect seen ...increase estrogen as in pregnency and ocp cause increase TBG...SO free harmone will bind to TBG and free t3 and t4 value goes down but total harmone (free and bound to tbg ) will remain same...
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Old 04-17-2012
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lol same thing...answer still applies
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Old 04-17-2012
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both said the same thing thank you!
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Old 04-18-2012
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Originally Posted by ajaja View Post
both said the same thing thank you!
Both are not same...add1@ said total -->increases

free t3, t4--> remain same...
How does it remain same when it binds to tbg actually it should DECREASE

What i was trying to say is:
total --->remain same

free t3,t4---> goes down

remaining other points where same that is tbg increase with estrogen..lol
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Old 04-18-2012
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Quote:
Originally Posted by add1 View Post
Estrogen increases the production of TBG. In effect, total T3 + T4 will increase but the free levels of T3 + T4 stay the same: The patient remains euthyroid.
kaplan says as free level remain same as u were saying but my doubt is when TBG increases free t3,t4 should bind to tbg and should decrease why its remaining same??...can any one plese explain??
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