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Old 05-24-2012
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ObGyn Indomethacin why 32 wks?

I was wondering why is the cut off point for the use of indomethacin is 32 wks. Im not looking for the shallow answer of closure of the ductus artriosus

IŽd like to know why was the 32 wks cut off point was chosen
I know there are a lot of very smart members on this forum that could help me out
thnx guys
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Old 05-24-2012
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Because the risk of premature ductal closure is much higher if you give Indomethacin after 32 weeks,

Here you go
http://www.ncbi.nlm.nih.gov/pubmed/9290437
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Old 05-24-2012
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Thumbs Up pda

ok so the cut off point of 32 is based on clinical evidence but theres not a clear underlying clear physiological explanation

I guess sometimes we have to learn some facts based on clinical evidence even if the underlying mechanism is not yet very well known

Thank you very much for the article, really appreciate it
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