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Old 06-04-2012
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Poison what is the cause of respiratory alkalosis in ASA toxicity ?

what is the cause of respiratory alkalosis in ASA toxicity ?

is it due to direct stimulation of respiratory centre or due to stimulation of respiratory centre by metabolic acidosis ?

how come it later turns in to respiratory acidosis ? fatigue ???
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Old 06-04-2012
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refer ch 23 KLN pediatrics pg 274 and KLN IM pg 334.......u will get ur answer
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Originally Posted by tyagee View Post
what is the cause of respiratory alkalosis in ASA toxicity ?

is it due to direct stimulation of respiratory centre or due to stimulation of respiratory centre by metabolic acidosis ?

how come it later turns in to respiratory acidosis ? fatigue ???

Respiratory centers are directly stimulated, causing a primary respiratory alkalosis. Salicylates also cause an inhibition of the citric acid cycle and an uncoupling of oxidative phosphorylation and may produce renal insufficiency that causes accumulation of phosphoric and sulfuric acids. The metabolism of fatty acids is likewise increased in patients with salicylate toxicity, generating ketone body formation. These processes all contribute to the development of an elevated anion-gap metabolic acidosis in patients with salicylate poisoning. This combination of a primary respiratory alkalosis and a primary metabolic acidosis is characteristic of salicylate poisoning,
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