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  #1  
Old 06-04-2012
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Virus what is best single prognostic indicator for AIDS?

what is best single prognostic indicator for AIDS?
CD4 count or viral load ?
why ?
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Old 06-04-2012
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Id say CD4 Count, viral load tends to fluctuate initially (spiking when pt has acute hiv syndrome etc.) .
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Old 06-04-2012
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CD4 mostly, cuz we weight every thing in regard to CD4 count (like prophylaxis...) but ?
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CD 4 count since most deaths are infection related and that's directly related to level of decrease in CD4 count.
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Old 06-04-2012
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In KLN pediatrics ,its written the best prognostic indicator of AIDS is HIV viral load......Is that not correct????
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Old 06-04-2012
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CD4 count

because: (From MTB 2 CK page 35): .....it is not HIV it self which leads to symptoms and death. rather, the depletion of the CD4 count leads to opportunistic infections that leads to illness
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HIV viral load - It appears that HIV viral load has the greatest prognostic value. HIV viral load in serum may be measured by assays which detect HIV-RNA e.g. RT-PCR, NASBA, or bDNA. HIV viral load has now been established as having good prognostic value, and in monitoring response to antiviral chemotherapy. Patients with a low viral load during the incubation period had a better prognosis than those with a high viral load. Patients whose viral load decreased significantly following the commencement of antiviral therapy had a better prognosis than those who did not respond.Among patients who responded to antiviral therapy, those who had a low pre-treatment viral load had a better prognosis than those who had a high pre-treatment viral load.

CD4 counts - despite the increasing use of HIV-RNA assays, measurement of CD4 still has important value in monitoring disease progression and response to antiviral chemotherapy. whereas CD4 count gives an indication of the stage of disease. “The measurement of HIV viral load tells us where the disease is going, whereas CD4 count tells us where the disease is at this moment”
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so ans to the question is

viral load and not CD4 count. right?
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Quote:
Originally Posted by tyagee View Post
so ans to the question is

viral load and not CD4 count. right?
Right...............
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Old 06-07-2012
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Warning! Latest KLN mentions...

Quote:
Originally Posted by tyagee View Post
so ans to the question is

viral load and not CD4 count. right?

Latest KLN mentios the following "CD4 is also the strongest predictor of disease progression and survival"
and regarding viral load "Monitoring of viral load is the best method to monitor adequate response to therapy"

so I guess CD4 is the answer?!!!
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Old 05-08-2015
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as I remember from Kumar textbook it is the viral load that determine the long-term prognosis (that is if you have high viral load after seroconversion ,then you have higher risk of developing AIDS in the next couple of years )
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