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Old 06-17-2012
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Drug ASA causes hyperkalemia or hypokalemia ?

ASA causes hyperkalemia or hypokalemia ?
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Old 06-17-2012
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Originally Posted by tyagee View Post
ASA causes hyperkalemia or hypokalemia ?
what do u mean by ASA?
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Originally Posted by usmle 99 View Post
what do u mean by ASA?
Aspirin. Lolz.
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Old 06-17-2012
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Aspirin

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Aspirin and other NSAIDs can cause hyperkalemia by inducing a hyporenin hypoaldosteronic state via inhibition of prostaglandin synthesis; however, these agents do not typically cause hyperkalemia by themselves in the setting of normal renal function and euvolemic state.
Salicylate Toxicity

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Hypokalemia and hypocalcemia can occur as a result of primary respiratory alkalosis.
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Originally Posted by Novobiocin View Post
Thanks.

Btw asa causesvasoconstriction of afferent arteriole. This decreases Renal blood flow. This should cause high renin.
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Old 07-07-2013
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I found this interesting that it couldnt be found in USMLE books but found the answer in MEdStudy Internal Medicine.

Yep. that means NSAIDs can both increase and decrease renin release, so they can make K+ go up or down. Interestingly, it's by ihe same mechanism: inhibition of a prostaglandin.

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