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Old 09-02-2016
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Default Q.why low TIBC in Anemia of chronic dz?

Q.Can anyone explain,
why there is low TIBC/transferrin in anemia of chronic disease?
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Old 09-03-2016
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TIBC increases when there is deficiency of iron. In anemia of chronic diseases there is no iron deficiency. The iron is just not available to the RBCs. The body does this by storing it in ferritin.
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Old 09-04-2016
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Nicely explained. Thanks Datson.
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Old 09-04-2016
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TIBC = Total Iron Binding capacity = It's in refinance to the amount of transport proteins in blood " TRANSFERRIN" and how much of that Protein is actually bound to Iron

Ferritin is a marker of Iron stores , Iron in bone morrow is bound to ferritin in order to prevent free radical formation by Iron , damaging the cells. Ferritin is also a marker for inflammation, reason why Ferritin tends to be normal in subset of patient that have iron deficiency anemia .


In Iron deficiency anemia, TIBC is High because of 2 reasons ..

1- The total body iron is low , So no Iron is around to attach to the transport proteins .

2- The body is depleted of it's Storage Iron " Ferritin " so it ramps up the production of transport proteins in the hope of delivering more iron back to the bone marrow in order to meet the demand .

Anemia of chronic disease .. is basically the opposite . The Iron is trapped in Bone marrow in order to prevent iron access to pathogens, preventing replication . And since Iron stores are High , the transport proteins are fully occupied and the body does not ramp up the production in order to replace it's storage.

Hopefully i didn't confuse you lol
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Old 09-05-2016
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Thanks compaque for casting more insight on this.
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