Q.why transfusion of Platelet is C/I in HUS/TTP? - USMLE Forums
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Old 09-07-2016
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Default Q.why transfusion of Platelet is C/I in HUS/TTP?

Q. What is the reason behind not transfusing platelets into patients with HUS OR TTP , when these conditions manifest with thrombocytopenia. Any explanation for how transfusion of PLT can worsen the condition?
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Old 09-09-2016
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They are causes of peripheral thrombocytopenia. You can transfuse as many platelets as you want but they will still end up in the same pathologic process as the ones your body makes = being destroyed for example. A transfusion would be more appropriate for a central thrombocytopenia - your body does not make enough so you transfuse some. In TTP/HUS platelets aggregate and make microthrombi which narrow the small arteries. So if you add more platelets you increase the risk of making the microthombi bigger. I'm not saying I'm 100% accurate on that but this is the way I understand it.
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Old 09-12-2016
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your explanation makes a lot of sense.Thanks Joe.
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