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Old 07-03-2012
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Question Booster effect and booster phenomenon !

This is excerpt form Kaplan CK Qbank that means it is relevant to CK.

Can you make sense out of it please!

booster effect means that an initially falsely negative tuberculin test can be boosted to a true positive test by the skin testing procedure itself
o Booster dose makes PPD preferred screening test for latent TB. It does not mean re infection.
Booster phenomenon: • It represents an increase in tuberculin skin test induration since a prior examination. • The first result is considered a false negative. • The second is the true measurement. • It occurs in people in whom TB infection has occurred many years ago and the delayed hypersensitivity is diminished.
please some one explain !
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Old 07-03-2012
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its basically the same thing

just stating the fact that -- IN a patient who is undergoing PPD testing for the first time-- 2 tests are done
the first PPD test... the result can be false negative.
(because of suppressed/diminished immune response)

hence a second PPD test must be done in quick succession ---
in which case the 1st dose just acts as the "booster" dose.. which re-activates the diminished immune response.
and the 2nd test is treated as the correct test used for interpretation
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