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Old 07-18-2012
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Idea! Differential Diagnosis of Proximal Muscle Weakness

What are the differential diagnoses of proximal muscle weakness??

A few that come to mind are
1 polymyositis/dermatomyositis
2 polymyalgia rheumatica
3 hypothyroidism
4 Myesthenia gravis

Any others?
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Old 07-18-2012
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inclusion body myositis
Eaton-Lambert syndrome
muscular dystrophy
hypokalemic periodic paralysis
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Old 07-18-2012
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PMR does not cause weakness
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Steroid-induced myopathy
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This can be helpful
Causes of Proximal Muscle Weakness

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2 more
Statins therapy
Cyclosporine
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Quote:
Originally Posted by K06100 View Post
inclusion body myositis

Inclusion body myositis (IBM) is an inflammatory muscle disease, characterized by slowly progressive weakness and wasting of both distal and proximal muscles
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Old 07-18-2012
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botulism
and usually presented with descending paralysis !
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Old 07-19-2012
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can we have dd for painful myopathy ? its sort of clue in solving questions to see if there is muscle pain or not along with proximal muscle weakness....one is hypokalemia,zidovudine... what are other causes ? would help us alot in exam i guess...

**thyroid myopathy is PAINLESS.
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Old 07-19-2012
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Quote:
Originally Posted by tyagee View Post
can we have dd for painful myopathy ?
Here you go..........

GENERALIZED MUSCLE PAIN: Differential Diagnosis

Myopathic pain: Usually with High CK & Abnormal EMG; Weakness common
Inflammatory
Inflammatory myopathies
Systemic connective tissue disease
tRNA synthetase antibodies
Childhood dermatomyositis
Muscle infections
Viral myositis
Pyomyositis
Toxoplasmosis
Trichinosis
Rhabdomyolysis ± Metabolic disorder
Myophosphorylase - McArdle's
Phosphofructokinase
Carnitine Palmitoyltransferase II
Mitochondrial myopathies
Malignant hyperthermia syndromes
Other myopathies with pain or myalgias
Myoadenylate deaminase
Myopathy with focal depletion of mitochondria
Myopathy with tubular aggregates ± cylindrical spirals
Myopathy with tubulin-reactive crystalline inclusions
Myopathy with hexagonally cross-linked crystalloid inclusions
Neuromyopathy with internalized capillaries
Myotonias: PROMM; Dominant myotonia congenita (Occasional)
Selenium deficiency
Toxic myopathy: Eosinophilia myalgia; Rhabdomyolysis
Hypothyroid myopathy
Mitochondrial disorders
Camurati-Engelmann syndrome
Vitamin D deficiency
Pain of muscle origin without chronic myopathy
Muscle ischemia: Atherosclerosis; Calciphylaxis; Diabetes
Cramps
Muscle overuse syndromes
Drugs & toxins
Delayed onset muscle soreness (DOMS)
Muscle injury (strain): External link-Iowa
Drugs & Toxins


Polymyalgia syndromes
Features
Muscle pain without weakness: Pain may interfere with effort
Pain: Present at rest; ± Increased with movement
Muscle tenderness: Diffuse or Multifocal
Serum CK: Normal
No pathologic changes in muscle
Disorders
Polymyalgia rheumatica
Fibromyalgia
Chronic fatigue syndrome
Infections
Viral & post-viral syndromes
Brucellosis; Leptospirosis; Falciparum malaria
Systemic connective tissue disorders: Sjögren's
Drugs & Toxins
Familial Mediterranean fever : Febrile myalgia syndrome
Non-muscle pain with defined origin
Polyneuropathy: Small fiber
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Old 07-20-2012
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LolZ. Can u short list IMp dd for ck ? :-)
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