Renal Manifestation in Hodgkin Lymphoma? - USMLE Forums
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Old 07-21-2012
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Kidney Renal Manifestation in Hodgkin Lymphoma?

A 36-year-old man comes to the physician because of fatigue and generalized edema. He was recently diagnosed with Hodgkin's lymphoma.
Urinalysis shows proteinuria 4+. Which of the following glomerulopathies is more likely to be present in this patient?

A. Focal segmental glomerulosclerosis
B. Membranous glomerulonephritis
C. Diffuse proliferative glomerulonephritis
D. Minimal change disease
E. Crescentic glomerulonephritis
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Old 07-21-2012
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B. Membranous glomerulonephritis
Don't know any explanation just a association.
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Old 07-21-2012
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One of the mysteries of step 2....

All other lymphomas give mainly membranous..

BUT HODGKINS give minimal change disease....probably from T cell activation which is implicated in the pathogenesis of minimal change disease....
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D. Minimal change disease associated with NSAID and hodgkin's lymphoma
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Old 07-22-2012
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Ans is indeed Hodgkins.

Hidgkin RS cell is B cell. Still it produces cytokines? Aren't T cells do cytokines stuff ? Just wondering ... Ya mcd pathophys is cytokines mediated damage ...


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Ans us MCD ... Oops


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Quote:
Originally Posted by tyagee View Post
Ans is indeed Hodgkins.

Hidgkin RS cell is B cell. Still it produces cytokines? Aren't T cells do cytokines stuff ? Just wondering ... Ya mcd pathophys is cytokines mediated damage ...


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Interleukin-21 is also produced by Hodgkin's lymphoma (HL) cancer cells (which is surprising because IL-21 was thought to be produced only in T cells).
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Hematology-, Internal-Medicine-, Nephrology-, Step-2-Questions

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