Do we have low haptglobin in any hemolysis? - USMLE Forums
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Old 08-11-2012
tyagee's Avatar
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RBC Do we have low haptglobin in any hemolysis?

does low haptoglobin means intravascular hemolysis or just hemolysis ?

if question mentions haptoglobin levels are low, does it just means hemolysis or intravascular hemolysis ?

i remember reading in Goljan that it means intravascular hemolysis but i did question in which it just meant hemolysis
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Old 08-11-2012
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heptglobin binds to the free Hb in the blood after ther RBC was destroyed, meaning if hemolytic anemia, the heptaglobin gets used--> low heptaglobin.
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Old 08-11-2012
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You have to understand the basic concept behind haptoglobin.
Haptoglobin binds free Hb. So, it's only decreased in intra-vascular hemolysis.
In extra-vascular hemolysis, the RBCs are phagocytosed by RE cells. So, there is no release of free Hb into the blood for it to bind haptoglobin.
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