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Old 08-19-2012
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Default beta 2 agonists hypoglycemia?

hey guys does anybdy knows why you get hypoglycemia with b2 qgonists? I can understand that b2 receptors in the liver causing glycogenolysis and on alpha cells of the pancreas will aid in the increase of glucose in the bloodstream but how about the b2 receptors in the beta cells of the pancreas, shouldnt that rise in insuline decreases de sugar lvl???
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Old 08-19-2012
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Originally Posted by mister View Post
hey guys does anybdy knows why you get hypoglycemia with b2 qgonists? I can understand that b2 receptors in the liver causing glycogenolysis and on alpha cells of the pancreas will aid in the increase of glucose in the bloodstream but how about the b2 receptors in the beta cells of the pancreas, shouldnt that rise in insuline decreases de sugar lvl???
B agonists increase insulin release from the beta cells in the pancrease, by adenylate Cyclades and that in turn increase intracellular calcium, just like the rise in ca+ that occurs after closing the k+ channels and cell depolarization upon glucose metabolism .

I hope that helps
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Old 08-19-2012
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b agonists increase insulin release from the beta cells in the pancrease, by adenylate cyclades and that in turn increase intracellular calcium, just like the rise in ca+ that occurs after closing the k+ channels and cell depolarization upon glucose metabolism .

I hope that helps
exactly, now here comes the confussing part from kaplan gyn\ob book page 73: : B2 agonists side effect hyperglycemia and hypokalemia.

I suspected hypokalemia was due to the increase in insulin, but i see hyperglycemia too, so the best thing i could came up with was that the effect of glycogenolysis and glucagon was more powerful than the effect of the insulin release....can anyone help correcting or agreeing with this??
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Old 08-19-2012
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It is logic to thing that b2 agonists cause hypoglycemia or hyperglycemia they both hace a good explanation to be. Im suspecting that this hyperglycemia thing is just one of those ¨thats just the way it is ¨ type of answer
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exactly, now here comes the confussing part from kaplan gyn\ob book page 73: : B2 agonists side effect hyperglycemia and hypokalemia.

I suspected hypokalemia was due to the increase in insulin, but i see hyperglycemia too, so the best thing i could came up with was that the effect of glycogenolysis and glucagon was more powerful than the effect of the insulin release....can anyone help correcting or agreeing with this??

Keep in mind that B2 agonists(adrenalin) are stress hormones, I.e increase blood glucose when we need it the most( running away from a tiger, lol), so you might be right about your hypothesis. I have no logic explanation thu.
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