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Old 07-26-2010
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Drug amiodarone and prolactin

Is amiodarone induced hypothyroidism causing raised or decreased prolactin?

Could anybody please explain?


Thanks.
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Old 07-27-2010
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Quote:
Originally Posted by studyhard View Post
Is amiodarone induced hypothyroidism causing raised or decreased prolactin?

Could anybody please explain?


Thanks.
Hypothyroidism causes hyperprolactinemia , as decrease Thyroid hormon causes .. Increase TRH , which have stimulatory effect on lactotrophs causes increase prolactin secretion ... causes s/s of hyperprolactinoma ..... In that Rx of hyperprolactinoma is thyroxin ....
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Old 07-27-2010
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Also read here
Amiodarone Hypo or Hyper thyroidism?
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Old 07-27-2010
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Originally Posted by FSUSTC View Post
Hypothyroidism causes hyperprolactinemia , as decrease Thyroid hormon causes .. Increase TRH , which have stimulatory effect on lactotrophs causes increase prolactin secretion ... causes s/s of hyperprolactinoma ..... In that Rx of hyperprolactinoma is thyroxin ....
Thanks.

I know that hypothyroidism in general can cause hyperprolactinemia. But, is there anything special about amiodarone induced hypothyroidism effect on prolactin?

See this:
http://www.ncbi.nlm.nih.gov/pubmed/3427795

I ask this because I want to know how to differentiate amiodarone induced hypothyroidism and other cause of hypothyroidism by reviewing the lab result. I am suspecting that 'prolactin' may be the key?

Thank you very much. Appreciated.
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Old 07-27-2010
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Originally Posted by Sabio View Post
Thanks.
I have read it. It is helpful.
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