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Old 09-09-2012
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Arrow Gyrus Daily Questions; Pediatrics #39

A 15 year old female presented to the emergency department with history of recurrent epistaxis, hematurua and hematochezia.There was a history of profuse bleeding from the umbilicus stump at birth.Previous investigations revealed normal prothrombin time, activated partial thromboplastin time,thrombin time and fibrinofen levels.Her platelet counts as well as platelet function tests were normal but urea lysis test was positive.Which one of the following clotting factor is most likely to be deficient ?

A. Factor X.
b. Factor XI
C. Factor XII
d. Factor XIII
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Old 09-09-2012
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ans .......D .......... didnt know about this had to search it .........
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Old 09-09-2012
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Quote:
Originally Posted by cingulate.gyrus View Post
A 15 year old female presented to the emergency department with history of recurrent epistaxis, hematurua and hematochezia.There was a history of profuse bleeding from the umbilicus stump at birth.Previous investigations revealed normal prothrombin time, activated partial thromboplastin time,thrombin time and fibrinofen levels.Her platelet counts as well as platelet function tests were normal but urea lysis test was positive.Which one of the following clotting factor is most likely to be deficient ?

A. Factor X.
b. Factor XI
C. Factor XII
d. Factor XIII
This is a new concept to me, so i did the search. I got the following:
Factor XIII(Fibrin stablizing factor) helps to stablize the clot after itīs formed. but if itīs absent cause dissolution of the clot and result in failure of haemostasis.
The first step in detection is a screening test know as urea lysis test in which the pt. sample in incubated with thrombin and Ca to form clot then place in a media containing 5M of urea and incubated for 24 hour, it if dissolves it mean XIII deficiency .
then to confirmt he deficiency then need quantitative assay of XIII.

So, the answer would be D
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Old 09-09-2012
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fibrin stabilizing factor>>> the Preserver (Vishnu) deficiency (Conrad Fischer lecture)

Thrombin>>> Brahma (the creator)

Plasmin
>>> Shiva (the destroyer)

Last edited by Novobiocin; 09-09-2012 at 04:12 PM.
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Old 09-09-2012
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Quote:
Originally Posted by Novobiocin View Post
fibrin stabilizing factor>>> the Preserver (Vishnu) deficiency (Conrad Fischer lecture)

Thrombin>>> Brahma (the creator)

Plasmin
>>> Shiva (the destroyer)

Bahooth Achaa...............Bahooth Achaaa.....Sathyam Sivam ..Sundaram.... Fischer..!!!

Last edited by cingulate.gyrus; 09-09-2012 at 08:20 PM. Reason: adding some thing
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