Find the true statement - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 2 CK Forum

USMLE Step 2 CK Forum USMLE Step 2 CK Discussion Forum: Let's talk about anything related to USMLE Step 2 CK exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 09-26-2012
K06100's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 730
Threads: 90
Thanked 456 Times in 289 Posts
Reputation: 466
Default Find the true statement

A 55-year-old woman who was successfully
treated with chemotherapy for breast cancer
several years ago presents to her primary care
physician complaining of 2 months of easy
bruising, bleeding gums, fatigue, and shortness
of breath. On physical examination she has a
low-grade fever and several bruises in different
locations on her body. She does not have jugular
venous distention. No masses are palpable
on breast examination. Heart and lung examination
are within normal limits. Abdominal examination
is signifi cant for hepatosplenomegaly.
Her WBC count is 35,000/mm≥. Her
WBCs are myeloperoxidase positive. Which of
the following statements regarding patients carrying
this diagnosis is true?

(A) Incidence decreases with increasing age
(B) Previous chemotherapy does not affect risk
for developing the disease
(C) Prognosis is not affected by the cytogenetics
of the disease
(D) Retinoic acid was once used to treat this
disease but is no longer part of the current
treatment
(E) They are at increased risk for stroke
__________________
Try Not To Become A Man Of Success But A Man Of Value.
Reply With Quote Quick reply to this message
The above post was thanked by:
anomali (09-26-2012)



  #2  
Old 09-26-2012
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 790
Threads: 76
Thanked 672 Times in 316 Posts
Reputation: 690
Default

I guess C........since the AML(if i'm not wrong) is secondary to the chemotherapy she received for breast cancer, the prognosis may not depend on the cytogenetics
__________________

To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts.

To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts.
Matched!!!
Reply With Quote Quick reply to this message
  #3  
Old 09-26-2012
Anders's Avatar
USMLE Forums Veteran
 
Steps History: 1+CK+CS
Posts: 289
Threads: 7
Thanked 129 Times in 102 Posts
Reputation: 139
Default

Quote:
Originally Posted by K06100 View Post
A 55-year-old woman who was successfully
treated with chemotherapy for breast cancer
several years ago presents to her primary care
physician complaining of 2 months of easy
bruising, bleeding gums, fatigue, and shortness
of breath. On physical examination she has a
low-grade fever and several bruises in different
locations on her body. She does not have jugular
venous distention. No masses are palpable
on breast examination. Heart and lung examination
are within normal limits. Abdominal examination
is signifi cant for hepatosplenomegaly.
Her WBC count is 35,000/mm≥. Her
WBCs are myeloperoxidase positive. Which of
the following statements regarding patients carrying
this diagnosis is true?

(A) Incidence decreases with increasing age
(B) Previous chemotherapy does not affect risk
for developing the disease
(C) Prognosis is not affected by the cytogenetics
of the disease
(D) Retinoic acid was once used to treat this
disease but is no longer part of the current
treatment
(E) They are at increased risk for stroke
Would go with C
Reply With Quote Quick reply to this message
  #4  
Old 09-27-2012
USMLE Forums Master
 
Steps History: 1+CK+CS
Posts: 851
Threads: 88
Thanked 706 Times in 379 Posts
Reputation: 716
Default

I will go with A ....
__________________
"Don't Forget they need us too"
Reply With Quote Quick reply to this message
  #5  
Old 09-27-2012
K06100's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 730
Threads: 90
Thanked 456 Times in 289 Posts
Reputation: 466
Default

The correct answer is E. This patient presents
with a thrombocytopenic picture and with leukocytosis.
Her positive myeloperoxidase test is
diagnostic for AML. Complications of this disease
include leukostasis leading to hyperviscosity
retinopathy, transient ischemic attacks/cerebrovascular
accidents, tumor lysis syndrome
(while undergoing treatment), gingival hyperplasia,
central nervous system involvement, recurrent
infection, and disseminated intravascular
coagulation (especially with M3 subtype).
Answer A is incorrect. The incidence of AML
increases with age. Persons with AML who are
>60 years old have a poor prognosis.
Answer B is incorrect. Environmental risk
factors for developing leukemia include radiation,
chemotherapy (especially with alkylating
agents and topoisomerase inhibitors), benzene
exposure, and smoking.
Answer C is incorrect. Cytogenetics and subtype
are extremely important in determining
prognosis and effectiveness of treatment in
AML. Poor prognostic factors include monosomies
of chromosomes 5 or 7, deletion of 5q,
and complex karyotype.
Answer D is incorrect. Retinoic acid will often
help induce remission in the promyelocytic
form of AML (M3 subtype).
__________________
Try Not To Become A Man Of Success But A Man Of Value.
Reply With Quote Quick reply to this message



Reply

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
Find the true statement K06100 USMLE Step 2 CK Forum 1 09-19-2012 05:51 PM
true or not true correlations !!! MARYAMB USMLE Step 1 Forum 2 09-10-2012 01:30 AM
I do not think I want to know this if it is true Hope2Pass USMLE Step 1 Forum 4 03-29-2012 12:52 PM
What's true about diverticuli! ricko335 USMLE Step 1 Forum 2 11-01-2011 08:19 AM
IS this true ? stepsdreamer USMLE Step 2 CS Forum 5 05-25-2010 05:24 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)