Numbness as clue in hyperaldosteronism - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
USMLE Articles
Go Back   USMLE Forums > USMLE Step 2 CK Forum

USMLE Step 2 CK Forum USMLE Step 2 CK Discussion Forum: Let's talk about anything related to USMLE Step 2 CK exam

Thread Tools Search this Thread Display Modes
Old 11-03-2012
tyagee's Avatar
USMLE Forums Master
Steps History: ---
Posts: 1,365
Threads: 648
Thanked 584 Times in 354 Posts
Reputation: 594
Question Numbness as clue in hyperaldosteronism

if q mentions numbness in primary hyperaldo, what can that be attributed to ? IMO, hypoK does not cause this
Reply With Quote Quick reply to this message

Old 11-04-2012
USMLE Forums Master
Steps History: 1+CK+CS
Posts: 1,868
Threads: 149
Thanked 2,078 Times in 1,046 Posts
Reputation: 2098

It is due to Metabolic alkalosis.

Low K causes plasma to borrow K from the cells. To maintain electroneurality H+ has to move inside the cell causing Metabolic alkalosis which in turn causes low ionized Ca+ leading to tingling & numbness despite normal total Ca+.

As blood plasma hydrogen ion concentration decreases, caused by respiratory or metabolic alkalosis, freely ionized calcium concentration decreases. This freely ionized calcium is the biologically active component of blood calcium. Since a portion of both hydrogen ions and calcium are bound to serum albumin, when blood becomes alkalotic, bound hydrogen ions dissociate from albumin, freeing up the albumin to bind with more calcium and thereby decreasing the freely ionized portion of total serum calcium. For every 0.1 increase in pH, ionized calcium decreases by about 0.05 mmol/L. This hypocalcaemia related to alkalosis is partially responsible for the cerebral vasoconstriction that causes the lightheadedness, fainting, and paraesthesia often seen with hyperventilation. Tetany may also be seen with this condition.
A man doesn't know what he knows until he knows what he doesn't know.
“What is man? He's just a collection of chemicals with delusions of grandeur.”
Reply With Quote Quick reply to this message
The above post was thanked by:
theundead (11-04-2012), tyagee (11-04-2012)


Clinical-Signs, Endocrinology-

Quick Reply

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Please enter a password for your user account. Note that passwords are case-sensitive.
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Where you live. Leave blank if you don't want to tell.


Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.

Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes

Similar Threads
Thread Thread Starter Forum Replies Last Post
Clinical Clue to Uncal Herniation! tyagee USMLE Step 2 CK Forum 6 02-28-2013 11:10 PM
hypertension as clue to medium vessel vasculitis ? tyagee USMLE Step 1 Forum 2 06-26-2012 08:12 AM
Peripheral nerve injury without numbness! USMLE-Syndrome USMLE Step 1 Forum 4 11-25-2011 01:30 PM
Tingling and Numbness after Thyroidectomy! drnrpatel USMLE Step 2 CK Forum 6 10-17-2011 12:49 PM
No clue on how to start CS Prep aspirant USMLE Step 2 CS Forum 2 03-01-2011 03:05 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2016 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)