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Old 11-03-2012
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Question Numbness as clue in hyperaldosteronism

if q mentions numbness in primary hyperaldo, what can that be attributed to ? IMO, hypoK does not cause this
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Old 11-04-2012
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It is due to Metabolic alkalosis.

Low K causes plasma to borrow K from the cells. To maintain electroneurality H+ has to move inside the cell causing Metabolic alkalosis which in turn causes low ionized Ca+ leading to tingling & numbness despite normal total Ca+.

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As blood plasma hydrogen ion concentration decreases, caused by respiratory or metabolic alkalosis, freely ionized calcium concentration decreases. This freely ionized calcium is the biologically active component of blood calcium. Since a portion of both hydrogen ions and calcium are bound to serum albumin, when blood becomes alkalotic, bound hydrogen ions dissociate from albumin, freeing up the albumin to bind with more calcium and thereby decreasing the freely ionized portion of total serum calcium. For every 0.1 increase in pH, ionized calcium decreases by about 0.05 mmol/L. This hypocalcaemia related to alkalosis is partially responsible for the cerebral vasoconstriction that causes the lightheadedness, fainting, and paraesthesia often seen with hyperventilation. Tetany may also be seen with this condition.
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